Protein Domain : IPR005922

Type:  Family Name:  Phenylalanine ammonia-lyase
Description:  The ubiquitous higher plant enzyme phenylalanine ammonia-lyase (PAL; ) is a key biosynthetic catalyst in phenylpropanoid assembly. PAL catalyses the non-oxidative deamination of L-phenylalanine to trans-cinnamic acid. PAL contains a catalytic Ala-Ser-Gly triad that is post-translationally cyclised. PAL is structurally similar to the mechanistically related histidine ammonia lyase (HAL; ), with PAL having an additional approximately 160 residues extending from the common fold []. Catalysis in PAL may be governed by the dipole moments of seven alpha helices associated with the PAL active site. The cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO) resides atop the positive poles of three helices, for increasing its electrophillicity. Plant and fungal PAL enzymes contain aa approximately 100-residue long C-terminal multi-helix domain, which might play a role in the rapid response of PAL in the regulation of phenylpropanoid biosynthesis by destabilising the enzyme []. Short Name:  Phe_NH3-lyase
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1 Child Features

DB identifier Type Name
IPR031008 Family Phenylalanine aminomutase (L-beta-phenylalanine forming)

2 Contains

DB identifier Type Name
IPR008948 Domain L-Aspartase-like
IPR022313 Active_site Phenylalanine/histidine ammonia-lyases, active site

1 Cross References

Identifier
TIGR01226

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0016841 IPR005922
GO:0006559 IPR005922
GO:0005737 IPR005922

3 Ontology Annotations

GO Term Gene Name
GO:0016841 IPR005922
GO:0006559 IPR005922
GO:0005737 IPR005922

1 Parent Features

DB identifier Type Name
IPR001106 Family Aromatic amino acid lyase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_2443.2 PAC:16414603 Carica papaya 557  
evm.model.supercontig_390.3 PAC:16419117 Carica papaya 716  
evm.model.supercontig_92.120 PAC:16428579 Carica papaya 716  
29912.m005291 B9RK33 PAC:16813170 Ricinus communis 688  
30078.m002319 B9S0K2 PAC:16817430 Ricinus communis 714  
29638.m000502 B9STU5 PAC:16804421 Ricinus communis 716  
28507.m000156 B9T0A8 PAC:16800993 Ricinus communis 719  
Cucsa.385970.1 A0A0A0KEL3 PAC:16982658 Cucumis sativus 713  
Cucsa.124460.1 PAC:16961715 Cucumis sativus 712  
Cucsa.124490.1 PAC:16961718 Cucumis sativus 717  
Cucsa.124510.1 A0A0A0KIE0 PAC:16961720 Cucumis sativus 705  
Cucsa.124470.1 PAC:16961716 Cucumis sativus 708  
Cucsa.124480.1 A0A0A0KF39 PAC:16961717 Cucumis sativus 713  
Cucsa.124500.1 PAC:16961719 Cucumis sativus 705  
Cucsa.124450.1 A0A0A0KEP3 PAC:16961714 Cucumis sativus 714  
orange1.1g037382m A0A067EHM7 PAC:18131279 Citrus sinensis 555  
orange1.1g004955m A0A067E5T0 PAC:18113980 Citrus sinensis 722  
AT5G04230.1 P45725 PAC:19673082 Arabidopsis thaliana 694  
AT5G04230.2 F4JW69 PAC:19673081 Arabidopsis thaliana 698  
AT3G10340.1 Q9SS45 PAC:19660032 Arabidopsis thaliana 707  
AT3G53260.1 P45724 PAC:19663780 Arabidopsis thaliana 717  
AT2G37040.1 P35510 PAC:19641262 Arabidopsis thaliana 725  
Thhalv10016314m V4NZC4 PAC:20180150 Eutrema salsugineum 724  
Thhalv10020168m V4M9I3 PAC:20181942 Eutrema salsugineum 708  
Thhalv10020170m V4LYW7 PAC:20181943 Eutrema salsugineum 706  
Thhalv10010153m V4LN43 PAC:20207298 Eutrema salsugineum 725  
Ciclev10011134m V4S3N9 PAC:20797379 Citrus clementina 757  
Ciclev10027912m V4SG43 PAC:20814092 Citrus clementina 714  
Ciclev10027913m V4RT50 PAC:20814546 Citrus clementina 714  
Ciclev10030821m V4TIW8 PAC:20804732 Citrus clementina 722  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15350127
            16478474