Protein Domain : IPR011608

Type:  Domain Name:  PRD domain
Description:  Transcriptional antiterminators and activators containing phosphoenolpyruvate: sugar phosphotransferase system (PTS) regulation domains (PRDs) form a class of bacterial regulatory proteins whose activity is modulated by phosphorylation. These regulators stimulate the expression of genes and operons involved in carbohydrate metabolism.PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria [, ] and are often characterised by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators, ) or DNA (for activators), and a duplicated PRD module which is phosphorylated on conserved histidines by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations are thought to modify the stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain [, , ]. PRDs are characterised by the presence of a duplicated regulatory module of ~100 residues that can be reversibly phosphorylated on histidyl residues by the PTS. PRDs in transcriptional antiterminators and activators are PTS regulatory targets that are (de)phosphorylated in response to the availability of carbon sources [, , , , ].The PRD domain comprises one and often two highly conserved histidines. It forms a compact bundle comprising five helices (alpha1-alpha5). The core of the PRD module consists of two pairs of antiparallel helices making an angle of ~60 degrees. The first pair contains the antiparallel helices alpha1 and alpha4, while the second pair contains alpha2 and alpha5. The third helix (alpha3) is oriented perpendicularly to alpha5 at the periphery of the bundle. The helices are connected by loops of varying length [, , ]. Short Name:  PRD
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0 Child Features

1 Contains

DB identifier Type Name
IPR001550 Conserved_site Transcription antiterminator, conserved site

4 Cross Referencess

Identifier
PF00874
PS51372
G3DSA:1.10.1790.10
SSF63520

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0006355 IPR011608

1 Ontology Annotations

GO Term Gene Name
GO:0006355 IPR011608

0 Parent Features

371 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_11.83 PAC:16405753 Carica papaya 133  
evm.model.supercontig_18.229 PAC:16411381 Carica papaya 736  
evm.model.supercontig_5.189 PAC:16421294 Carica papaya 693  
evm.model.supercontig_66.41 PAC:16424605 Carica papaya 87  
Cucsa.018300.1 PAC:16951801 Cucumis sativus 852  
AT3G57140.2 Q9M1I6 PAC:19658737 Arabidopsis thaliana 801  
AT3G57140.1 Q9M1I6 PAC:19658736 Arabidopsis thaliana 801  
Thhalv10005816m V4L237 PAC:20190489 Eutrema salsugineum 702  
Potri.006G175100.1 A0A2K2A3V2 PAC:27004220 Populus trichocarpa 89  
15694 A4RYK4 PAC:27418222 Ostreococcus lucimarinus 179  
Thecc1EG024457t2 A0A061EXD4 PAC:27424408 Theobroma cacao 849  
Thecc1EG024457t1 A0A061EXD4 PAC:27424407 Theobroma cacao 849  
Migut.F00207.2.p PAC:28932205 Mimulus guttatus 467  
Migut.F00207.1.p PAC:28932206 Mimulus guttatus 467  
Araha.3772s0010.1.p PAC:28841557 Arabidopsis halleri 796  
Araha.11097s0011.1.p PAC:28847675 Arabidopsis halleri 473  
Cagra.0578s0045.1.p PAC:28898737 Capsella grandiflora 801  
Glyma.01G103000.1.p A0A0R0LIC3 PAC:30544389 Glycine max 213  
Glyma.02G190000.1.p K7K9F9 PAC:30506191 Glycine max 805  
Glyma.03G130900.1.p I1JN82 PAC:30515703 Glycine max 844  
Glyma.19G132900.1.p I1N8V2 PAC:30514504 Glycine max 840  
Brara.G01727.1.p A0A397YTT9 PAC:30635171 Brassica rapa FPsc 787  
Bostr.30456s0001.1.p PAC:30667206 Boechera stricta 514  
Bostr.20505s0031.1.p PAC:30674553 Boechera stricta 802  
Cre14.g617250.t1.2 A8HNU2 PAC:30776562 Chlamydomonas reinhardtii 187  
Medtr1g087300.1 G7IDS5 PAC:31095413 Medicago truncatula 829  
Medtr6g090505.1 A0A072UBP1 PAC:31104825 Medicago truncatula 364  
Medtr6g080170.1 A0A072UBX6 PAC:31102598 Medicago truncatula 835  
Medtr7g025210.1 G7KYW1 PAC:31081519 Medicago truncatula 383  
SapurV1A.1773s0010.1.p PAC:31436147 Salix purpurea 842  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1732212
            9045813
            11751049
            11733988
            11447120
            15699035
            9202047
            9663674