Protein Domain : IPR012985

Type:  Family Name:  Peptidase S64, Ssy5
Description:  Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes []. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identified, these being grouped into clans on the basis of structural similarity and other functional evidence []. Structures are known for members of the clans and the structures indicate that some appear to be totally unrelated, suggesting different evolutionary origins for the serine peptidases [].Not withstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base []. The geometric orientations of the catalytic residues are similar between families, despite different protein folds []. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (PA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [, ].This family of fungal proteins is involved in the processing of membrane bound transcription factor Stp1 [] and belongs to MEROPS petidase family S64 (clan PA). The processing causes the signalling domain of Stp1 to be passed to the nucleus where several permease genes are induced. The permeases are important for uptake of amino acids, and processing of tp1 only occurs in an amino acid-rich environment. This family is predicted to be distantly related to the trypsin family (MEROPS peptidase family S1) and to have a typical trypsin-like catalytic triad []. Short Name:  Peptidase_S64_Ssy5
Paste the following link

0 Child Features

1 Contains

DB identifier Type Name
IPR009003 Domain Peptidase S1, PA clan

2 Cross Referencess

Identifier
PF08192
PIRSF011716

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

10 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_10.46 PAC:16404661 Carica papaya 458  
Thhalv10016435m V4NYU5 PAC:20179658 Eutrema salsugineum 577  
Thhalv10016432m V4MAJ4 PAC:20179657 Eutrema salsugineum 578  
Brara.E00920.1.p A0A397ZC00 PAC:30623689 Brassica rapa FPsc 577  
Pp3c21_5360V3.1.p A0A2K1IQS3 PAC:32916374 Physcomitrium patens 621  
Pp3c21_5360V3.2.p A0A2K1IQS3 PAC:32916375 Physcomitrium patens 621  
Isati.3509s0009.1.p PAC:39348771 Isatis tinctoria 577  
Camar.3073s0002.1.p PAC:39642988 Cakile maritima 578  
Camar.3073s0002.2.p PAC:39642989 Cakile maritima 577  
Crahi.0089s0003.1.p PAC:39983675 Crambe hispanica 320  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8439290
            7845208
            15509782