Protein Domain : IPR020587

Type:  Domain Name:  DNA recombination and repair protein RecA, monomer-monomer interface
Description:  The recA gene product is a multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response []. In homologous recombination, the protein functions as a DNA-dependent ATPase, promoting synapsis, heteroduplex formation and strand exchange between homologous DNAs []. RecA also acts as a protease cofactor that promotes autodigestion of the lexA product and phage repressors. The proteolytic inactivation of the lexA repressor by an activated form of recA may cause a derepression of the 20 or so genes involved in the SOS response, which regulates DNA repair, induced mutagenesis, delayed cell division and prophage induction in response to DNA damage []. RecA is a protein of about 350 amino-acid residues. Its sequence is very well conserved [, , ] among eubacterial species. It is also found in the chloroplast of plants []. RecA-like proteins are found in archaea and diverse eukaryotic organisms, like fission yeast, mouse or human. In the filamentvisualised by X-ray crystallography, beta-strand 3, the loop C-terminal to beta-strand 2, and alpha-helix D of the core domain form one surface that packs against alpha-helix A and beta-strand 0 (the N-terminal domain) of an adjacent monomer during polymerisation []. The core ATP-binding site domain is well conserved, with 14 invariant residues. It contains the nucleotide binding loop between beta-strand 1 andalpha-helix C. The Escherichia colisequence GPESSGKT matches the consensus sequence of amino acids (G/A)XXXXGK(T/S) for the Walker A box (also referred to as the P-loop) found in a number of nucleoside triphosphate (NTP)-binding proteins. Anothernucleotide binding motif, the Walker B box is found at beta-strand 4 in the RecA structure. The Walker B box is characterised by four hydrophobic amino acids followed by an acidic residue (usually aspartate). Nucleotide specificity and additional ATP binding interactions are contributed by the amino acid residues at beta-strand 2 and the loop C-terminal to thatstrand, all of which are greater than 90% conserved among bacterial RecA proteins.The signature in this entry spans the entire monomer-monomer interface in RecA proteins. Short Name:  RecA_monomer-monomer_interface
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0 Child Features

1 Contains

DB identifier Type Name
IPR020584 Conserved_site DNA recombination/repair protein RecA, conserved site

1 Cross References

Identifier
PS50163

5 Found Ins

DB identifier Type Name
IPR013765 Family DNA recombination and repair protein RecA
IPR013632 Domain DNA recombination and repair protein Rad51, C-terminal
IPR016467 Family DNA recombination and repair protein, RecA-like
IPR011940 Family Meiotic recombinase Dmc1
IPR011938 Family DNA recombination/repair protein RadA

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR020587
GO:0005524 IPR020587
GO:0008094 IPR020587
GO:0006259 IPR020587

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR020587
GO:0005524 IPR020587
GO:0008094 IPR020587
GO:0006259 IPR020587

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_10.24 PAC:16404604 Carica papaya 449  
evm.model.supercontig_182.28 PAC:16411579 Carica papaya 368  
evm.model.supercontig_344.4 PAC:16418081 Carica papaya 340  
evm.model.supercontig_44.128 PAC:16420133 Carica papaya 333  
evm.model.supercontig_61.12 PAC:16423826 Carica papaya 393  
29739.m003680 B9RR28 PAC:16807459 Ricinus communis 294  
29844.m003214 B9RTJ3 PAC:16810921 Ricinus communis 353  
29912.m005338 B9RK79 PAC:16813216 Ricinus communis 380  
30053.m000104 B9T6M8 PAC:16816117 Ricinus communis 388  
29650.m000274 B9SVD4 PAC:16804871 Ricinus communis 343  
Cucsa.040390.1 PAC:16952765 Cucumis sativus 410  
Cucsa.040390.2 PAC:16952766 Cucumis sativus 320  
Cucsa.117070.5 A0A0A0LFR1 PAC:16960670 Cucumis sativus 507  
Cucsa.117080.1 A0A0A0LIM6 PAC:16960671 Cucumis sativus 422  
Cucsa.117080.2 PAC:16960672 Cucumis sativus 406  
Cucsa.117080.3 PAC:16960673 Cucumis sativus 342  
Cucsa.117070.1 PAC:16960666 Cucumis sativus 508  
Cucsa.142090.1 A0A0A0M2A5 PAC:16963583 Cucumis sativus 340  
Cucsa.018030.1 PAC:16951768 Cucumis sativus 401  
Cucsa.254660.1 PAC:16972283 Cucumis sativus 345  
orange1.1g016151m PAC:18134121 Citrus sinensis 394  
orange1.1g021239m PAC:18134122 Citrus sinensis 315  
orange1.1g019381m A0A067G2F0 PAC:18125985 Citrus sinensis 342  
orange1.1g047388m A0A067GGE2 PAC:18106035 Citrus sinensis 352  
orange1.1g013567m A0A067EHN3 PAC:18123702 Citrus sinensis 440  
orange1.1g017792m A0A067E2Z2 PAC:18113093 Citrus sinensis 366  
orange1.1g014268m A0A067DZ11 PAC:18113092 Citrus sinensis 427  
AT5G20850.1 P94102 PAC:19671792 Arabidopsis thaliana 342  
AT3G10140.1 Q8RY99 PAC:19659556 Arabidopsis thaliana 389  
AT3G22880.1 Q39009 PAC:19663360 Arabidopsis thaliana 344  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7592482
            8587109
            1896024
            1518831
            9187054
            12045091