Protein Domain : IPR024165

Type:  Family Name:  Aminoglycoside 3-phosphotransferase
Description:  Aminoglycoside antibiotics constitute an important class of clinically useful drugs, including gentamicin, tobramycin, and streptomycin, which are used in the treatment of a variety of bacterial infections []. They work by targeting the bacterial ribosome and causing mistranslation of mRNA, leading to the production of defective proteins. In many cases these defective proteins insert into the cell membrane, causing a loss of membrane integrity and precipitating cell death. The most common cause of resistance to these antibiotics is their modification by acetylating, adenylating or phosphorylating enzymes.This entry represents aminoglycoside 3'-phosphotransferases, one of the best characterised aminoglycoside-resistance enzyme families. These enzymes transfer a phophoryl group from ATP to the 3' position of the aminoglycoside molecule. Studies indicate that these enzymes are both structurally and functionally homologous to eukaryotic protein kinases [, , ]. The enzyme contains two domains, an N-terminal domain composed mainly of an antiparallel beta sheet, and a C-terminal domain which is largely alpha helical. The active site lies between these domains and comprises both the ATP binding site and the aminoglycoside binding site. Short Name:  Kan/Strep_kinase
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR21310
PIRSF000706

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005524 IPR024165
GO:0016773 IPR024165
GO:0046677 IPR024165

3 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR024165
GO:0016773 IPR024165
GO:0046677 IPR024165

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.TU.contig_32743.2 PAC:16430154 Carica papaya 273  
35928.m000020 B9TF02 PAC:16826793 Ricinus communis 296  
DCAR_023301 PAC:36058996 Daucus carota 313  
Zm00001d007158_P013 A0A1D6F4C0 PAC:40189079 Zea mays 278  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11467935
            12006485
            12628253
            9872733