Protein Domain : IPR012708

Type:  Family Name:  2-methylisocitrate dehydratase AcnD, Fe/S-dependent
Description:  This entry represents Fe/S-dependent 2-methylisocitrate dehydratase (AcnD; ), which is part of the 2-methylcitrate (2-MC) cycle that occurs in certain fungi and bacteria. The 2-MC cycle is involved in the degradation of propionyl-CoA via 2-methylcitrate, with AcnD functioning after PrpD and before PrpB. AcnD acts to catalyse the dehydration of 2-methylcitrate and citrate to 2-methyl-cis-aconitate and cis-aconitate, respectively, as well as to catalyse the hydration of cis-aconitate. However, 2-methylisocitrate and isocitrate were not substrates for AcnD, indicating that AcnD only catalyses the first half of the aconitase-like dehydration reactions []. The enzyme from the fungus Yarrowia lipolytica(Candida lipolytica) does not act on isocitrate. AcnD is homologous to aconitases A and B. In Escherichia coli, which lacks a member of this family, 2-methylisocitrate dehydratase activity was traced to aconitase B () []. Short Name:  2Me_IsoCit_deHydtase_FeS-dep
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0 Child Features

4 Contains

DB identifier Type Name
IPR015931 Domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
IPR000573 Domain Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
IPR001030 Domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
IPR015932 Domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2

1 Cross References

Identifier
TIGR02333

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR015934 Family Aconitase/2-methylisocitrate dehydratase

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1011171m.p PAC:33659148 Brachypodium distachyon Pangenome 864  
Brdisv1BdTR11A1041105m.p PAC:35694850 Brachypodium distachyon BdTR11a 864  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12473114
            14702315