Protein Domain : IPR003724

Type:  Family Name:  ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR
Description:  ATP:cob(I)alamin (or ATP:corrinoid) adenosyltransferases (), catalyse the conversion of cobalamin (vitamin B12) into its coenzyme form, adenosylcobalamin (AdoCbl)or coenzyme B12 []. AdoCbl contains an adenosyl moiety liganded to the cobalt ion of cobalamin via a covalent Co-C bond. AdoCbl is required as a cofactor for the activity of certain enzymes. ATP:cob(I)alamin adenosyltransferases are classed into three groups: CobA-type [], EutT-type [] and PduO-type []. Each of the three enzyme types appears to be specialised for particular AdoCbl-dependent enzymes or for the de novo synthesis AdoCbl. PduO and EutT are distantly related, sharing short conserved motifs, while CobA is evolutionarily unrelated and is an example of convergent evolution. This entry represents the ATP:cob(I)alamin adenosyltransferases CobA (Salmonella typhimurium), CobO (Pseudomonas denitrificans), and ButR (Escherichia coli). There is a high degree of sequence identity between these proteins []. CobA is responsible for attaching the adenosyl moiety from ATP to the cobalt ion of the corrin ring, necessary for the convertion of cobalamin to adenosylcobalamin [, ]. Short Name:  CblAdoTrfase_CobA
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF02572
PIRSF015617
TIGR00708

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005524 IPR003724
GO:0008817 IPR003724
GO:0009236 IPR003724

3 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR003724
GO:0008817 IPR003724
GO:0009236 IPR003724

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1009801m.p PAC:33623872 Brachypodium distachyon Pangenome 489  
Brdisv1BdTR11A1047288m.p PAC:35688024 Brachypodium distachyon BdTR11a 489  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11160088
            15317775
            16672609
            15516577
            7916712