Protein Domain : IPR029762

Type:  Family Name:  Pyroglutamyl peptidase I, bacterial-type
Description:  This group of cysteine peptidases belong to MEROPS peptidase family C15 (pyroglutamyl peptidase I, clan CF). The type example being pyroglutamyl peptidase I of Bacillus amyloliquefaciens. Pyroglutamyl/pyrrolidone carboxyl peptidase (Pcp or PYRase) is an exopeptidase that hydrolytically removes the pGlu from pGlu-peptides or pGlu-proteins [, ].PYRase has been found in prokaryotes and eukaryotes where at least two different classes have been characterised: the first containing bacterial and animal type I PYRases, and the second containinganimal type II and serum PYRases. Type I and bacterial PYRases are soluble enzymes, while type II PYRases are membrane-bound. The primary applicationof PYRase has been its utilisation for protein or peptide sequencing, and bacterial diagnosis []. The conserved residues Cys-144 and His-168 havebeen identified by inhibition and mutagenesis studies [, ].This family consist of bacterial and archaeal type I PYRases. Short Name:  PGP-I_bact-type
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
TIGR00504
MF_00417

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008234 IPR029762
GO:0016920 IPR029762
GO:0006508 IPR029762
GO:0005829 IPR029762

4 Ontology Annotations

GO Term Gene Name
GO:0008234 IPR029762
GO:0016920 IPR029762
GO:0006508 IPR029762
GO:0005829 IPR029762

1 Parent Features

DB identifier Type Name
IPR000816 Family Peptidase C15, pyroglutamyl peptidase I

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1007006m.p PAC:33624312 Brachypodium distachyon Pangenome 213  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1353026
            7909543
            7824521