Protein Domain : IPR013458

Type:  Family Name:  Aldose 1-epimerase, bacterial
Description:  Aldose 1-epimerase () (mutarotase) is the enzyme responsible for the anomeric interconversion of D-glucose and other aldoses between their alpha- and beta-forms. The sequence of mutarotase from two bacteria, Acinetobacter calcoaceticusand Streptococcus thermophilusis available []. It has also been shown that, on the basis of extensive sequence similarities, a mutarotase domain seems to be present in the C-terminal half of the fungal GAL10 protein that encodes, in the N-terminal part, UDP-glucose 4-epimerase. The best conserved region in the sequence of mutarotase is cantered around a conserved histidine residue which may be involved in the catalytic mechanism.Galactose mutarotases (D-galactose 1-epimerase) participate in the Leloir pathway for galactose/glucose interconversion. Genes encoding the proteins found in this entry are found clustered with genes encoding other enzymes of the Leloir pathway. These proteins belong to the aldose 1-epimerase family. However, the aldose 1-epimerase itself () has a relatively broad specificity and can utilise D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. The restricted genomic context of the genes suggests members should act primarily on D-galactose. Short Name:  Ald_epimerase_bac
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0 Child Features

2 Contains

DB identifier Type Name
IPR014718 Domain Glycoside hydrolase-type carbohydrate-binding, subgroup
IPR018052 Conserved_site Aldose 1-epimerase, conserved site

1 Cross References

Identifier
TIGR02636

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004034 IPR013458
GO:0006012 IPR013458

2 Ontology Annotations

GO Term Gene Name
GO:0004034 IPR013458
GO:0006012 IPR013458

1 Parent Features

DB identifier Type Name
IPR015443 Family Aldose 1-epimerase

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1005597m.p PAC:33635561 Brachypodium distachyon Pangenome 322  
Brdisv1pangenome1006896m.p PAC:33619706 Brachypodium distachyon Pangenome 320  
Brdisv1BdTR11A1029442m.p PAC:35681400 Brachypodium distachyon BdTR11a 322  
Brdisv1BdTR11A1041694m.p PAC:35690402 Brachypodium distachyon BdTR11a 320  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1694527