Protein Domain : IPR010161

Type:  Family Name:  Peptidase M20B, tripeptide aminopeptidase
Description:  Metalloproteases are the most diverse of the four main types of protease, with more than 50 families identified to date. In these enzymes, a divalent cation, usually zinc, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. The known metal ligands are His, Glu, Asp or Lys and at least one other residue is required for catalysis, which may play an electrophillic role. Of the known metalloproteases, around half contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site []. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [].This entry represents metallopeptidases belonging to MEROPS peptidase family M20 (clan MH), subfamily M20B. They are tripeptide aminopeptidases commonly known as Peptidase T, which have a substrate preference for hydrophobic peptides. Short Name:  Peptidase_M20B
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0 Child Features

2 Contains

DB identifier Type Name
IPR011650 Domain Peptidase M20, dimerisation domain
IPR001261 Conserved_site ArgE/DapE/ACY1/CPG2/YscS, conserved site

3 Cross Referencess

Identifier
PIRSF037215
TIGR01882
MF_00550

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008270 IPR010161
GO:0045148 IPR010161
GO:0006518 IPR010161
GO:0005737 IPR010161

4 Ontology Annotations

GO Term Gene Name
GO:0008270 IPR010161
GO:0045148 IPR010161
GO:0006518 IPR010161
GO:0005737 IPR010161

1 Parent Features

DB identifier Type Name
IPR002933 Family Peptidase M20

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1000443m.p PAC:33620242 Brachypodium distachyon Pangenome 807  
Brdisv1BdTR12c1005891m.p PAC:34393718 Brachypodium distachyon BdTR12c 807  
Solyc00g024030.1.1 PAC:36127899 Solanum lycopersicum 415  
Solyc00g024030.1.1 PAC:41467147 Solanum lycopersicum 415  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7674922