Protein Domain : IPR017421

Type:  Family Name:  Mitogen-activated protein (MAP) kinase kinase kinase 7
Description:  This entry represents mitogen-activated protein kinase kinase kinase 7 (MAP3K7), which is a component of a protein kinase signal transduction cascade, acting as a mediator of TGF-beta signal transduction. MAP3K7 stimulates NF-kappa-B (NFKB) activation and the p38 MAPK pathway. MAP3K7 binds both upstream activators and downstream substrates in multi-molecular complexes. It appears to interact with MAP3K7IP1 and MAP3K7IP2, as well as with PPM1L. The interaction of MAP3K7 with PP2A and PPP6C leads to its' repressed activity.A small deletion of MAP3K7 and four other genes was found to be strongly associated with high-grade prostate cancers []. Short Name:  MAPKKK7

0 Child Features

3 Contains

DB identifier Type Name
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References


0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0000287 IPR017421
GO:0004709 IPR017421
GO:0007165 IPR017421

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID