Protein Domain : IPR014376

Type:  Family Name:  Protein kinase C, delta/epsilon/eta/theta types
Description:  This entry represents the novel protein kinase C (nPKC) family.The N-terminal regulatory domain of nPKC consists of a C2 domain follows by a double C1 domain (C1A and C1B). The C2 domain does not respond to calcium which makes nPKC diacylglycerol-sensitive but calcium-independent [, , ].PKC is a family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol [, ]. Members of this family play key regulatory roles in various cellular processes. Currently, there are ten isoforms of PKC which can be classified into classical (alpha, beta I, beta II, gamma), novel (delta, epsilon, eta, theta) and atypical (zeta, iota/lambda) types based on their primary structure and biochemical characteristics [, , ]. All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain. Short Name:  Prot_kin_PKC_delta

4 Child Features

DB identifier Type Name
IPR027436 Family Protein kinase C, delta
IPR027431 Family Protein kinase C, eta
IPR027274 Family Protein kinase C, epsilon
IPR027264 Family Protein kinase C, theta

7 Contains

DB identifier Type Name
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR000008 Domain C2 domain
IPR002219 Domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR017892 Domain Protein kinase, C-terminal
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site
IPR020454 Domain Diacylglycerol/phorbol-ester binding

1 Cross References

Identifier
PIRSF000551

0 Found In

2 GO Annotations

GO Term Gene Name Organism
GO:0004697 IPR014376
GO:0006468 IPR014376

0 Parent Features

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            199594
            7358670
            9601053
            17661083
            9792904
            19033211
            1411571
            12359062