Protein Domain : IPR020676

Type:  Family Name:  Death-associated protein kinase 1
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry represents death-associated protein kinases 1 (DAPK1). It act as a positive regulator of apoptosis [, , , , ]. Short Name:  DAPK1

0 Child Features

7 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR020683 Domain Ankyrin repeat-containing domain
IPR002110 Repeat Ankyrin repeat
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References

Identifier
PTHR22964:SF54

0 Found In

0 GO Annotation

1 Parent Features

DB identifier Type Name
IPR020675 Family Myosin light chain kinase-related

0 Proteins

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            9488481
            10376525
            10629061
            11230133
            11485996