Protein Domain : IPR008271

Type:  Active_site Name:  Serine/threonine-protein kinase, active site
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , ]are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in the catalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue, which is important for the catalytic activity of the enzyme []. This signature contains the active site aspartate residue. Short Name:  Ser/Thr_kinase_AS

0 Child Features

0 Contains

1 Cross References

Identifier
PS00108

51 Found Ins

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR020636 Family Calcium/calmodulin-dependent/calcium-dependent protein kinase
IPR015783 Family Serine/threonine-protein kinase HT1, plant
IPR008351 Family Mitogen-activated protein (MAP) kinase, JNK
IPR017348 Family Serine/threonine-protein kinase pim-1/2/3
IPR020679 Family Serine/threonine-protein kinase Tda1
IPR020675 Family Myosin light chain kinase-related
IPR015725 Family Telokin/Myosin light chain kinase
IPR015726 Family Serine/threonine protein kinase, striated muscle-specific
IPR020676 Family Death-associated protein kinase 1
IPR020684 Family Rho-associated protein kinase 1/2
IPR020682 Family Obscurin-myosin light chain kinase
IPR017322 Family Receptor-interacting serine/threonine-protein kinase 2
IPR003527 Conserved_site Mitogen-activated protein (MAP) kinase, conserved site
IPR015785 Family Mitogen-activated protein (MAP) kinase kinase kinase 10
IPR016231 Family Mitogen-activated protein (MAP) kinase kinase kinase, MLK1/MLK2/MLK4
IPR016234 Family Serine/threonine-protein kinase, Sbk1
IPR016235 Family Tyrosine/threonine-protein kinase, Cdc2 inhibitor
IPR016237 Family Serine/threonine-protein kinase, Ulk1/Ulk2
IPR016240 Family Serine/threonine-protein kinase YKL116C, predicted
IPR016241 Family Nitrogen network kinase 1
IPR016242 Family Serine/threonine-protein kinase Mps1
IPR017090 Family Serine/threonine-protein kinase, SIK1/2
IPR017164 Family Wee1-like protein kinase
IPR017184 Family Serine/threonine-protein kinase Unc-51
IPR017239 Family Mitogen-activated protein (MAP) kinase kinase kinase Ste11, Cryptococcus
IPR017419 Family Mitogen-activated protein kinase kinase kinase 12/13
IPR017424 Family Mitogen-activated protein (MAP) kinase kinase kinase 8

2 GO Annotations

GO Term Gene Name Organism
GO:0004672 IPR008271
GO:0006468 IPR008271

0 Parent Features

0 Proteins

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            7768349
            1835513
            1956325
            1862342