| Type: | Family | Name: | Squalene cyclase |
| Description: | Several enzymes catalyse mechanistically related reactions which involve the highly complex cyclic rearrangement of squalene or its 2,3 oxide.Lanosterol synthase () (oxidosqualene--lanosterol cyclase) catalyses the cyclization of (S)-2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D invertebrates and of ergosterol in fungi (gene ERG7). Cycloartenol synthase () (2,3-epoxysqualene--cycloartenol cyclase), is a plant enzyme that catalyzes the cyclization of (S)-2,3-epoxysqualene to cycloartenol, and hopene synthase () (squalene--hopene cyclase), is a bacterialenzyme that catalyzes the cyclization of squalene into hopene, a key step in hopanoid (triterpenoid) metabolism.These enzymes are evolutionary related [] proteins of about 70 to 85 kD. This entry represents squalene cyclase. | Short Name: | Squalene_cyclase |
