3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0018343 | IPR026872 |
| GO:0042127 | IPR026872 |
| GO:0005965 | IPR026872 |
| Type: | Family | Name: | Protein farnesyltransferase subunit beta |
| Description: | Protein farnesyltransferase (FTase) is an enzyme responsible for the posttranslational modification (farnesylation) of proteins carrying a carboxy-terminal CaaX motif, including Ras, Ras homologues, and other small G proteins. FTase catalyses the transfer of a farnesyl moiety from farnesyl pyrophosphate to the cysteine at the CaaX motif, where a is a small aliphatic amino acid and X is the carboxy-terminal residue [, ].FTase is a heterodimeric complex comprised of a regulatory alpha subunit shared with geranylgeranyltransferase I (also a CaaX prenyltransferase) and a unique catalytic beta subunit []. FTase plays important roles in the growth and differentiation of eukaryotic cells. It is essential for embryonic proliferation, but dispensable for adult homeostasis []. In plants, is involved in abscisic acid signal transduction, which modulates a variety of developmental processes and responses to environmental stress []. In yeast, protein farnesylation is important for maintaining normal cell morphology [] and for cell cycle progression []. | Short Name: | FTB |
| GO Term | Gene Name |
|---|---|
| GO:0018343 | IPR026872 |
| GO:0042127 | IPR026872 |
| GO:0005965 | IPR026872 |
