| Type: | Domain | Name: | Ras GTPase-activating protein |
| Description: | This entry represents a conserved domain in the RasGAPs (Ras GTPase-activating proteins). This domain is also known as the RasGAP domain. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP []. This intrinsic GTPase activity of Ras is regulated by a family of proteins collectively known as 'GAP' or GTPase-activating proteins [, ]. RasGAP proteins are usually quite large (from 765 residues for sar1 to 3079residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or RasGAP domain.The most conserved region within this domain contains a 15 residue motif which seems to be characteristic of this family of proteins []. Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of Ras-like proteins (reviewed in reference []) that do not share sequence similarity with ras GAPs. | Short Name: | RasGAP_dom |
