Protein Domain : IPR024931

Type:  Family Name:  Importin subunit alpha
Description:  The exchange of macromolecules between the nucleus and cytoplasm takes place through nuclear pore complexes within the nuclear membrane. Active transport of large molecules through these pore complexes require carrier proteins, called karyopherins (importins and exportins), which shuttle between the two compartments.Members of the importin-alpha (karyopherin-alpha) family can form heterodimers with importin-beta. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Proteins can contain one (monopartite) or two (bipartite) NLS motifs. Importin-alpha contains several armadillo (ARM) repeats, which produce a curving structure with two NLS-binding sites, a major one close to the N terminus and a minor one close to the C terminus.Ran GTPase helps to control the unidirectional transfer of cargo. The cytoplasm contains primarily RanGDP and the nucleus RanGTP through the actions of RanGAP and RanGEF, respectively. In the nucleus, RanGTP binds to importin-beta within the importin/cargo complex, causing a conformational change in importin-beta that releases it from importin-alpha-bound cargo. The N-terminal importin-beta-binding (IBB) domain of importin-alpha contains an auto-regulatory region that mimics the NLS motif []. The release of importin-beta frees the auto-regulatory region on importin-alpha to loop back and bind to the major NLS-binding site, causing the cargo to be released [].This entry represents importin alpha. Short Name:  Importing_su_alpha
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0 Child Features

0 Contains

1 Cross References

Identifier
PIRSF005673

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008565 IPR024931
GO:0006606 IPR024931
GO:0005634 IPR024931
GO:0005737 IPR024931

4 Ontology Annotations

GO Term Gene Name
GO:0008565 IPR024931
GO:0006606 IPR024931
GO:0005634 IPR024931
GO:0005737 IPR024931

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
105015 D8RZ74 PAC:15411826 Selaginella moellendorffii 532  
evm.model.supercontig_48.134 PAC:16420767 Carica papaya 542  
29805.m001477 B9SGQ4 PAC:16809183 Ricinus communis 517  
Cucsa.153170.1 PAC:16964653 Cucumis sativus 516  
Cucsa.153170.2 PAC:16964654 Cucumis sativus 455  
orange1.1g043950m A0A067D670 PAC:18098088 Citrus sinensis 458  
orange1.1g039940m A0A067D853 PAC:18122281 Citrus sinensis 449  
orange1.1g042204m A0A067EAX4 PAC:18108770 Citrus sinensis 559  
orange1.1g009647m PAC:18104537 Citrus sinensis 530  
orange1.1g010080m PAC:18104538 Citrus sinensis 518  
orange1.1g043676m A0A067DHN4 PAC:18129209 Citrus sinensis 446  
orange1.1g043116m A0A067DMG1 PAC:18124069 Citrus sinensis 482  
AT5G49310.1 Q9FJ09 PAC:19673150 Arabidopsis thaliana 519  
AT5G52000.1 Q9FJ92 PAC:19667100 Arabidopsis thaliana 441  
AT3G05720.1 Q9M9X7 PAC:19659423 Arabidopsis thaliana 528  
Thhalv10020485m V4LG84 PAC:20183400 Eutrema salsugineum 535  
Thhalv10005613m V4K493 PAC:20198270 Eutrema salsugineum 504  
Ciclev10011496m V4SN13 PAC:20798765 Citrus clementina 518  
Lus10001480 PAC:23157126 Linum usitatissimum 509  
Lus10016850 PAC:23179042 Linum usitatissimum 512  
Lus10008480 PAC:23177357 Linum usitatissimum 509  
Potri.016G086600.1 B9IJ11 PAC:27013164 Populus trichocarpa 522  
Gorai.001G248100.1 A0A0D2PWE2 PAC:26823698 Gossypium raimondii 519  
Gorai.006G080400.1 A0A0D2Q5E8 PAC:26829625 Gossypium raimondii 526  
Thecc1EG026737t1 A0A061F2P5 PAC:27421876 Theobroma cacao 599  
Thecc1EG026737t4 A0A061F3X2 PAC:27421877 Theobroma cacao 530  
Migut.L01665.1.p A0A022REV1 PAC:28934991 Mimulus guttatus 520  
Araha.16901s0007.1.p PAC:28862957 Arabidopsis halleri 442  
Araha.24789s0005.1.p PAC:28857074 Arabidopsis halleri 529  
Cagra.2108s0008.1.p PAC:28912502 Capsella grandiflora 538  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17170104
            8692858