1 Child Features
| DB identifier | Type | Name |
|---|---|---|
| IPR025763 | Family | tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote |
| Type: | Family | Name: | tRNA (guanine-N-7) methyltransferase, Trmb type |
| Description: | This entry represents tRNA (guanine-N-7) methyltransferase (), which catalyses the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Capping of the pre-mRNA 5' end by addition a monomethylated guanosine cap (m(7)G) is an essential and the earliest modification in the biogenesis of mRNA []. The reaction is catalysed by three enzymes: triphosphatase, guanylyltransferase, and tRNA (guanine-N-7) methyltransferase [, ]. This entry includes Bacillus subtilis TrmB, which contains a a unique variant of the Rossmann-fold methyltransferase (RFM) structure, with the N-terminal helix folded on the opposite site of the catalytic domain [].Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor. | Short Name: | tRNA_(Gua-N-7)_MeTrfase_Trmb |
| DB identifier | Type | Name |
|---|---|---|
| IPR025763 | Family | tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote |
