Protein Domain : IPR027065

Type:  Family Name:  Lon protease
Description:  Lon protease belongs to the S16 peptidase family and is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins, as well as certain short-lived regulatory proteins. It is required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress []. In pathogenic bacteria, it is required for the expression of virulence genes that promote cell infection [].Lon (La) protease was the first ATP-dependent protease to be purified from E. coli [, , , ]. The enzyme is a homotetramer of 87kDa subunits, with one proteolytic and one ATP-binding site per monomer, making it structurally less complex than other known ATP-dependent proteases []. Despite this relative structural simplicity, Lon recognises its substrates directly, without delegating the task of substrate recognition to other enzymes []. Short Name:  Lon_Prtase
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6 Child Features

DB identifier Type Name
IPR004815 Family Lon protease, bacterial/eukaryotic-type
IPR004663 Family Lon protease, archaeal
IPR014251 Family Sporulation protease LonB
IPR014252 Family Sporulation protease LonC
IPR027501 Family Lon protease homologue 2, peroxisomal
IPR027503 Family Lon protease homolog, chloroplastic/mitochondrial

0 Contains

1 Cross References

Identifier
PTHR10046

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004176 IPR027065
GO:0004252 IPR027065
GO:0005524 IPR027065
GO:0030163 IPR027065

4 Ontology Annotations

GO Term Gene Name
GO:0004176 IPR027065
GO:0004252 IPR027065
GO:0005524 IPR027065
GO:0030163 IPR027065

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
141788 D8QWE3 PAC:15412071 Selaginella moellendorffii 879  
30423 D8QXF0 PAC:15414090 Selaginella moellendorffii 928  
405160 D8QWE9 PAC:15410905 Selaginella moellendorffii 432  
444435 D8SAJ0 PAC:15416609 Selaginella moellendorffii 432  
evm.model.supercontig_48.159 PAC:16420794 Carica papaya 868  
evm.model.supercontig_48.158 PAC:16420793 Carica papaya 57  
evm.model.supercontig_76.10 PAC:16425976 Carica papaya 800  
30074.m001376 B9S715 PAC:16816939 Ricinus communis 313  
30128.m008906 B9RFI8 PAC:16818492 Ricinus communis 680  
50511.m000014 B9TC07 PAC:16828274 Ricinus communis 297  
29628.m000786 B9SS30 PAC:16803929 Ricinus communis 890  
Cucsa.321520.1 A0A0A0L5B9 PAC:16977510 Cucumis sativus 886  
Cucsa.321520.2 PAC:16977511 Cucumis sativus 756  
Cucsa.090710.1 PAC:16957342 Cucumis sativus 972  
Cucsa.061530.1 A0A0A0KW98 PAC:16954898 Cucumis sativus 332  
orange1.1g005548m A0A067GSQ9 PAC:18108181 Citrus sinensis 691  
orange1.1g004834m A0A067EFQ2 PAC:18123513 Citrus sinensis 728  
orange1.1g003349m A0A067EC00 PAC:18123512 Citrus sinensis 828  
orange1.1g023183m A0A067GZ73 PAC:18092201 Citrus sinensis 286  
AT5G26860.1 P93655 PAC:19670419 Arabidopsis thaliana 940  
AT5G47040.1 O64948 PAC:19667678 Arabidopsis thaliana 888  
AT3G05790.1 Q9M9L7 PAC:19659523 Arabidopsis thaliana 942  
AT3G05780.1 Q9M9L8 PAC:19665240 Arabidopsis thaliana 924  
Thhalv10022093m PAC:20182885 Eutrema salsugineum 843  
Thhalv10000767m V4N3J1 PAC:20202645 Eutrema salsugineum 887  
Thhalv10003617m V4KQD6 PAC:20199596 Eutrema salsugineum 935  
Ciclev10003535m V4SJK2 PAC:20787040 Citrus clementina 269  
Ciclev10000120m V4TB01 PAC:20786751 Citrus clementina 1043  
Ciclev10018825m V4TTY1 PAC:20806462 Citrus clementina 863  
Ciclev10018797m V4TJ04 PAC:20806461 Citrus clementina 886  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9425059
            8294008
            3042779
            8226758
            10672180
            17216028