| Type: | Domain | Name: | Agenet-like domain |
| Description: | Fragile X Mental Retardation Protein (FMRP), and its autosomal paralogues, Fragile X mental Retardation syndrome-related protein 1 and 2 (FXR1 and FXR2),comprise a family of RNA-binding proteins. It is thought that the FRMP family of proteins contributes to the regulation of protein synthesis at sites wheremRNAs are locally translated in response to stimuli. These proteins are highly similar to one another and also retain highly conserved domain architecture.The two ribonucleoprotein K homology (KH) domains and the cluster of arginine and glycine residues that constitute the RGG box, comprisea large region that is important for RNA binding and polyribosome association. In addition, two Agenet-like domains exist in tandem within the N-terminalregions of FMRP family proteins. The Agenet-like domain belongs to the "Royal" domain superfamilly which contains also the Tudor, chromo, MBT, PWWP and plantAgenet domains. Biochemical analysis of the tandem Agenet-like domains reveals their ability to preferentially recognise trimethylated peptides in asequence-specific manner [, , , ].The Agenet-like domain folds into a bent four-stranded antiparallel beta sheet with a fifth strand closing the cavity of the sheet, similar to a thumbacross a semiclosed hand [, ]. | Short Name: | Agenet-like_dom |
