Type: | Domain | Name: | ALIX V-shaped domain |
Description: | The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding. In ALIX, a component of the ESCRT pathway, this domain is central between an N-terminal Bro1 domain () and a C-terminal proline-rich domain. The ALIX central domain is formed by two three-helix bundles disposed in a V shape [, ]. Retroviruses thus used this domain to hijack the ESCRT system of the cell []. | Short Name: | ALIX_V_dom |