Protein Domain : IPR016641

Type:  Family Name:  Nascent polypeptide-associated complex subunit alpha
Description:  In Saccharomyces cerevisiae, nascent polypeptide-associated complex subunit alpha (also known as EGD2) is a component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting [, , ]. In human and mouse, nascent polypeptide-associated complex subunit alpha (known as NACA) prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER [, ]. Short Name:  EGD2/NACA
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0 Child Features

1 Contains

DB identifier Type Name
IPR002715 Domain Nascent polypeptide-associated complex NAC domain

2 Cross Referencess

Identifier
PTHR21713
PIRSF015901

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
102471 D8RVN1 PAC:15406140 Selaginella moellendorffii 214  
evm.model.supercontig_3.162 PAC:16416438 Carica papaya 217  
evm.model.supercontig_33.158 PAC:16417606 Carica papaya 203  
29764.m000739 B9S5M4 PAC:16808164 Ricinus communis 228  
29686.m000885 B9SHV0 PAC:16805796 Ricinus communis 131  
29641.m000398 B9SX66 PAC:16804502 Ricinus communis 687  
Cucsa.358640.4 PAC:16980483 Cucumis sativus 200  
Cucsa.358640.6 PAC:16980485 Cucumis sativus 184  
Cucsa.358640.5 PAC:16980484 Cucumis sativus 200  
Cucsa.358640.1 PAC:16980480 Cucumis sativus 222  
Cucsa.358640.3 PAC:16980482 Cucumis sativus 200  
Cucsa.358640.2 PAC:16980481 Cucumis sativus 200  
orange1.1g028762m A0A067F2E7 PAC:18123215 Citrus sinensis 204  
orange1.1g028761m A0A067DXU4 PAC:18132591 Citrus sinensis 204  
orange1.1g028782m A0A067DXU4 PAC:18132592 Citrus sinensis 204  
orange1.1g030484m A0A067EA65 PAC:18132593 Citrus sinensis 176  
orange1.1g028127m A0A067DGW1 PAC:18127199 Citrus sinensis 213  
orange1.1g028148m A0A067DHA3 PAC:18127198 Citrus sinensis 213  
orange1.1g028211m A0A067DT60 PAC:18127200 Citrus sinensis 212  
AT4G10480.2 A8MQP6 PAC:19645279 Arabidopsis thaliana 211  
AT4G10480.1 Q9SZY1 PAC:19645278 Arabidopsis thaliana 212  
AT5G13850.1 Q6ICZ8 PAC:19665557 Arabidopsis thaliana 204  
AT3G12390.1 Q9LHG9 PAC:19661391 Arabidopsis thaliana 203  
AT3G49470.1 Q94JX9 PAC:19658892 Arabidopsis thaliana 217  
AT1G33040.1 Q8LGC6 PAC:19649077 Arabidopsis thaliana 209  
Thhalv10021544m V4LY52 PAC:20182642 Eutrema salsugineum 203  
Thhalv10010701m V4M092 PAC:20207293 Eutrema salsugineum 221  
Thhalv10014712m V4LCA0 PAC:20203584 Eutrema salsugineum 203  
Thhalv10014708m V4KTQ9 PAC:20203583 Eutrema salsugineum 204  
Thhalv10029431m V4N0L0 PAC:20197028 Eutrema salsugineum 264  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10518932
            9482879
            10512867
            9877153
            8698236