Protein Domain : IPR002072

Type:  Domain Name:  Nerve growth factor-related
Description:  During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to targetcells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells controltheir degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential forneuron survival. One of these is nerve growth factor (NGF or beta-NGF), a vertebrate protein that stimulates division and differentiation of sympathetic and embryonic sensory neurons [, ]. NGF is mostly found outside the centralnervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has alsobeen found in several snake venoms [, ].NGF is a protein of about 120 residues that is cleaved from a larger precursor molecule. It contains six cysteines all involved in intrachaindisulphide bonds. A schematic representation of the structure of NGF is shown below:+------------------------+| | | |xxxxxxCxxxxxxxxxxxxxxxxxxxxxCxxxxCxxxxxCxxxxxxxxxxxxxCxCxxxx | | | |+--------------------------|-----+ | +---------------------+'C': conserved cysteine involved in a disulphide bond. This entry also contains NGF-related proteins such as neutrophin 3, which promotes the survival of visceral and proprioceptive sensory neurons, and brain-derived neurotrophin, which promotes the survival of neuronal populations that are located either in the central nervous system or directly connected to it [, ]. Short Name:  Nerve_growth_factor-rel
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0 Child Features

1 Contains

DB identifier Type Name
IPR019846 Conserved_site Nerve growth factor conserved site

4 Cross Referencess

Identifier
PF00243
PR00268
PD002052
SM00140

7 Found Ins

DB identifier Type Name
IPR015578 Family Neurotrophin-3
IPR020408 Family Nerve growth factor-like
IPR020425 Family Nerve growth factor, beta subunit
IPR020430 Family Brain-derived neurotrophic factor
IPR020431 Family Neurotrophin-6
IPR020432 Family Neurotrophin-4
IPR020433 Family Venom nerve growth factor

1 GO Annotation

GO Term Gene Name
GO:0005102 IPR002072

1 Ontology Annotations

GO Term Gene Name
GO:0005102 IPR002072

1 Parent Features

DB identifier Type Name
IPR029034 Domain Cystine-knot cytokine

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Zosma164g00310.1 A0A0K9PU14 PAC:33167455 Zostera marina 60  
Urofu.1G413700.1.p PAC:50124571 Urochloa fusca 590  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3589669
            1477101
            2369898
            1995338
            8488558
            2236018
            8527932