Protein Domain : IPR000960

Type:  Family Name:  Flavin monooxygenase FMO
Description:  Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes []. Using an NADPH cofactor and FAD prosthetic group, these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorous and selenium atoms in a range of structurally diverse compounds. FMOs have been implicated in the metabolism of a number of pharmaceuticals, pesticides and toxicants. In man, lack of hepatic FMO-catalysed trimethylamine metabolism results in trimethylaminuria (fish odour syndrome). Five mammalian forms of FMO are now known and have been designated FMO1-FMO5 [, , , , ]. This is a recent nomenclature based on comparison of amino acid sequences, and has been introduced in an attempt to eliminate confusion inherent in multiple, laboratory-specific designations and tissue-based classifications []. Following the determination of the complete nucleotide sequence of Saccharomyces cerevisiae(Baker's yeast) [], a novel gene was found to encode a protein with similarity to mammalian monooygenases. Short Name:  Flavin_mOase
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1 Child Features

DB identifier Type Name
IPR012143 Family Dimethylaniline monooxygenase, N-oxide-forming

0 Contains

1 Cross References

Identifier
PR00370

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004499 IPR000960
GO:0050660 IPR000960
GO:0050661 IPR000960
GO:0055114 IPR000960

4 Ontology Annotations

GO Term Gene Name
GO:0004499 IPR000960
GO:0050660 IPR000960
GO:0050661 IPR000960
GO:0055114 IPR000960

1 Parent Features

DB identifier Type Name
IPR020946 Family Flavin monooxygenase-like

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
413950 D8RR55 PAC:15418320 Selaginella moellendorffii 408  
413958 D8RR63 PAC:15418336 Selaginella moellendorffii 446  
175034 D8RX27 PAC:15417568 Selaginella moellendorffii 439  
80431 D8QWM0 PAC:15405270 Selaginella moellendorffii 404  
266739 D8QZ00 PAC:15410651 Selaginella moellendorffii 494  
evm.TU.contig_30554.1 PAC:16429842 Carica papaya 401  
evm.model.supercontig_13.309 PAC:16407835 Carica papaya 403  
evm.model.supercontig_20.194 PAC:16412997 Carica papaya 81  
evm.model.supercontig_20.191 PAC:16412994 Carica papaya 521  
evm.model.supercontig_26.77 PAC:16415321 Carica papaya 385  
evm.model.supercontig_29.133 PAC:16416159 Carica papaya 445  
evm.model.supercontig_78.87 PAC:16426268 Carica papaya 421  
evm.model.supercontig_82.77 PAC:16427116 Carica papaya 521  
evm.model.supercontig_87.71 PAC:16427742 Carica papaya 425  
evm.model.supercontig_9.164 PAC:16428051 Carica papaya 373  
29720.m000138 B9T603 PAC:16806541 Ricinus communis 519  
29739.m003708 B9RR56 PAC:16807487 Ricinus communis 521  
29848.m004706 B9RPC4 PAC:16811361 Ricinus communis 421  
29912.m005525 B9RKR3 PAC:16813400 Ricinus communis 410  
30138.m004025 B9RLT7 PAC:16819390 Ricinus communis 457  
30170.m014354 B9R8M4 PAC:16822187 Ricinus communis 517  
30178.m000873 B9SMR1 PAC:16822847 Ricinus communis 517  
30178.m000874 B9SMR2 PAC:16822848 Ricinus communis 517  
30178.m000875 B9SMR3 PAC:16822849 Ricinus communis 517  
30178.m000876 B9SMR4 PAC:16822850 Ricinus communis 517  
29648.m001923 B9S2N4 PAC:16804765 Ricinus communis 386  
29648.m001924 B9S2N5 PAC:16804766 Ricinus communis 380  
28455.m000365 B9SUX5 PAC:16800873 Ricinus communis 62  
28455.m000364 B9SUX4 PAC:16800872 Ricinus communis 423  
28455.m000367 B9SUV7 PAC:16800875 Ricinus communis 510  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8311461
            1417778
            2318837
            1712018
            8486656
            1542660
            8091229