1 Child Features
| DB identifier | Type | Name |
|---|---|---|
| IPR017550 | Domain | Formylmethanofuran dehydrogenase subunit C |
3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016491 | IPR002489 |
| GO:0008152 | IPR002489 |
| GO:0055114 | IPR002489 |
| Type: | Domain | Name: | Glutamate synthase, alpha subunit, C-terminal |
| Description: | Glutamate synthase (GltS) is a complex iron-sulphur flavoprotein that catalyses the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the bacterial, yeast and plant pathways for ammonia assimilation []. GltS is a multifunctional enzyme that functions through three distinct active centres carrying out multiple reaction steps: L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor. The active centres are synchronised to avoid the wasteful consumption of L-glutamine []. There are three classes of GltS, which share many functional properties: bacterial NADPH-dependent GltS, ferredoxin-dependent GltS from photosynthetic cells, and NAD(P)H-dependent GltS from yeast, fungi and lower animals.The dimeric alpha subunits each consist of four domains: N-terminal amidotransferase domain, the central domain, the FMN binding domain and the C-terminal domain. The C-terminal domain forms a right-handed beta-helix that comprises seven helical turns []. Each helical turn has a sharp bend that is associated with a repeated sequence motif consisting of G-XX-G-XXX-G. This domain does not contain any residues directly involved in catalysis, but has a crucial structural role.This domain is also found in proteins such as subunit C of formylmethanofuran dehydrogenase, which catalyses the first step in methane formation from carbon dioxide in methanogenic archaea. There are two isoenzymes of formylmethanofuran dehydrogenase: a tungsten-containing isoenzyme (FwdC) and a molybdenum-containing isoenzyme (FmdC). The tungsten isoenzyme is constitutively transcribed, whereas transcription of the molybdenum operon is induced by molybdate []. | Short Name: | Glu_synth_asu_C |
| DB identifier | Type | Name |
|---|---|---|
| IPR017550 | Domain | Formylmethanofuran dehydrogenase subunit C |
| GO Term | Gene Name |
|---|---|
| GO:0016491 | IPR002489 |
| GO:0008152 | IPR002489 |
| GO:0055114 | IPR002489 |
