Protein Domain : IPR007537

Type:  Family Name:  tRNAHis guanylyltransferase Thg1
Description:  tRNA His molecules are unusual in having an extra 5' GMP residue (G(-1)) that, in eukaryotes, is added after transcription and RNase P cleavage. Incorporation of this G(-1) residue is a rare example of nucleotide addition occurring at an RNA 5' end in a normal phosphodiester linkage. In Saccharomyces cerevisiae, YGR024c (Thg1p) protein is responsible for this guanylyltransferase reaction []. It catalyses the guanylyltransferase step of G(-1) addition using a ppp-tRNA His substrate, and appears to catalyse the activation step using p-tRNA His and ATP. Thus, it catalyses phosphodiester bond formation at the 5' end of RNAs, formally in a 3'-5' direction []. Thg1 has also been shown to interact with the origin recognition complex and to be required for the G2/M phase transition [], and to have polymerase activity []. The polymerase activity has been proposed to be the ancestral activity of this enzyme []. Short Name:  tRNAHis_GuaTrfase_Thg1
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR12729
PIRSF028980

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0000287 IPR007537
GO:0008193 IPR007537
GO:0006400 IPR007537

3 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR007537
GO:0008193 IPR007537
GO:0006400 IPR007537

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
232047 D8RQV2 PAC:15416608 Selaginella moellendorffii 251  
evm.TU.contig_44268.1 PAC:16431986 Carica papaya 79  
33067.m000035 B9TJS9 PAC:16825679 Ricinus communis 185  
27758.m000330 B9SW90 PAC:16799122 Ricinus communis 524  
Cucsa.101490.1 A0A0A0KFW7 PAC:16958705 Cucumis sativus 520  
orange1.1g016392m PAC:18092952 Citrus sinensis 390  
orange1.1g009745m PAC:18092951 Citrus sinensis 527  
AT2G31580.1 F4IRQ5 PAC:19641938 Arabidopsis thaliana 567  
AT2G32320.2 F4ISV6 PAC:19643174 Arabidopsis thaliana 537  
AT2G32320.1 F4ISV6 PAC:19643176 Arabidopsis thaliana 525  
AT2G32320.3 F4ISV6 PAC:19643175 Arabidopsis thaliana 532  
Thhalv10016524m V4LMG3 PAC:20180498 Eutrema salsugineum 520  
Lus10041070 PAC:23179801 Linum usitatissimum 585  
Lus10006155 PAC:23148556 Linum usitatissimum 247  
Potri.002G233300.1 A0A2K2BN94 PAC:27023817 Populus trichocarpa 519  
Gorai.009G178600.1 A0A0D2TLN4 PAC:26762147 Gossypium raimondii 524  
Gorai.009G178600.2 A0A0D2UP67 PAC:26762148 Gossypium raimondii 466  
37376 I0YT96 PAC:27391492 Coccomyxa subellipsoidea C-169 257  
Thecc1EG030226t1 A0A061GH40 PAC:27440206 Theobroma cacao 523  
Migut.B00934.1.p PAC:28945758 Mimulus guttatus 383  
Araha.6424s0008.1.p PAC:28843853 Arabidopsis halleri 520  
Cagra.1626s0002.2.p PAC:28904425 Capsella grandiflora 445  
Cagra.1626s0002.1.p PAC:28904424 Capsella grandiflora 497  
Cagra.0352s0021.1.p PAC:28897317 Capsella grandiflora 200  
Cagra.6622s0008.1.p PAC:28918189 Capsella grandiflora 528  
Glyma.10G001600.1.p I1L7C6 PAC:30475093 Glycine max 511  
Glyma.16G091600.2.p K7MG44 PAC:30559561 Glycine max 510  
Glyma.16G091600.1.p K7MG44 PAC:30559560 Glycine max 510  
Glyma.16G129500.1.p I1MN70 PAC:30559841 Glycine max 298  
Glyma.16G117600.1.p A0A0R0FPP7 PAC:30559099 Glycine max 472  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14633974
            15821142
            20080734
            16731615