3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005215 | IPR001046 |
| GO:0006810 | IPR001046 |
| GO:0016020 | IPR001046 |
| Type: | Family | Name: | NRAMP family |
| Description: | The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functionally related proteins defined by a conserved hydrophobic core of ten transmembrane domains []. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+amongst others. It is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals []. The yeast proteins Smf1 and Smf2 may also transport divalent cations [].The natural resistance of mice to infection with intracellular parasites is controlled by the Bcg locus, which modulates the cytostatic/cytocidalactivity of phagocytes. Nramp1, the gene responsible, is expressed exclusively in macrophages and poly-morphonuclear leukocytes, and encodes a polypeptide(natural resistance-associated macrophage protein) with features typical of integral membrane proteins. Other transporter proteins from a variety of sources also belongto this family. | Short Name: | NRAMP_fam |
| GO Term | Gene Name |
|---|---|
| GO:0005215 | IPR001046 |
| GO:0006810 | IPR001046 |
| GO:0016020 | IPR001046 |
