| Type: | Family | Name: | Retinoblastoma-related protein |
| Description: | This entry contains retinoblastoma-related proteins mainly from plants. In humans, the retinoblastoma (RB) protein is a tumor suppressor linked to several major cancers []. It functions in cell cycle regulation to hold cells in G1 phase by binding to and inactivating members of the E2F family of transcription factors. The target genes of E2F transcription factor complexes encode proteins that are required for passage into S-phase, such as Cyclin E. Phosphorylation of the retinoblastoma protein by Cyclin D/Cdk4/6 complexes results in its inactivation and the release of the E2F proteins [].RB was originally thought to be specific to animals, but plants contain homologues called retinoblastoma-related (RBR) proteins. In addition to their role in cell-cycle progression [, ], RBRs have been shown to participate in various cellular processes such as stem cell maintenance, endoreplication, transcriptional regulation, chromatin remodelling, cell growth, and differentiation [, ]. | Short Name: | RBR |
