Protein Domain : IPR001753

Type:  Family Name:  Crotonase superfamily
Description:  The crotonase superfamily is comprised of mechanistically diverse proteins that share a conserved trimeric quaternary structure (sometimes a hexamer consisting of a dimer of trimers), the core of which consists of 4 turns of a (beta/beta/alpha)n superhelix. Some enzymes in the superfamily have been shown to display dehalogenase, hydratase, and isomerase activities, while others have been implicated in carbon-carbon bond formation and cleavage as well as the hydrolysis of thioesters []. However, these different enzymes share the need to stabilise an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two structurally conserved peptidic NH groups that provide hydrogen bonds to the carbonyl moieties of the acyl-CoA substrates and form an "oxyanion hole". The CoA thioester derivatives bind in a characteristic hooked shape and a conserved tunnel binds the pantetheine group of CoA, which links the 3'-phosphate ADP binding site to the site of reaction []. Enzymes in the crotonase superfamily include:Enoyl-CoA hydratase (crotonase; ), which catalyses the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA []. 3-2trans-enoyl-CoA isomerase (or dodecenoyl-CoA isomerise; ), which shifts the 3-double bond of the intermediates of unsaturated fatty acid oxidation to the 2-trans position [].3-hydroxbutyryl-CoA dehydratase (crotonase; ), a bacterial enzyme involved in the butyrate/butanol-producing pathway.4-Chlorobenzoyl-CoA dehalogenase (), a Pseudomonas enzyme which catalyses the conversion of 4-chlorobenzoate-CoA to 4-hydroxybenzoate-CoA [].Dienoyl-CoA isomerise, which catalyses the isomerisation of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA [].Naphthoate synthase (MenB, or DHNA synthetase; ), a bacterial enzyme involved in the biosynthesis of menaquinone (vitamin K2) []. Carnitine racemase (gene caiD), which catalyses the reversible conversion of crotonobetaine to L-carnitine in Escherichia coli[]. Methylmalonyl CoA decarboxylase (MMCD; ), which has a hexameric structure (dimer of trimers) [].Carboxymethylproline synthase (CarB), which is involved in carbapenem biosynthesis [].6-oxo camphor hydrolase, which catalyses the desymmetrisation of bicyclic beta-diketones to optically active keto acids [].The alpha subunit of fatty oxidation complex, a multi-enzyme complex that catalyses the last three reactions in the fatty acid beta-oxidation cycle [].AUH protein, a bifunctional RNA-binding homologue of enoyl-CoA hydratase []. Short Name:  Crotonase_core_superfam
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11 Child Features

DB identifier Type Name
IPR010198 Family 1,4-Dihydroxy-2-naphthoyl-CoA synthase, MenB
IPR012802 Family Fatty oxidation complex, alpha subunit FadJ
IPR012799 Family Fatty oxidation complex, alpha subunit FadB
IPR012803 Family Fatty acid oxidation complex, alpha subunit, mitochondrial
IPR017623 Family 2-ketocyclohexanecarboxyl-CoA hydrolase
IPR009188 Family [NiFe]-hydrogenase maturation factor, HypX/HoxX type
IPR022852 Family Carnitinyl-CoA dehydratase
IPR017602 Family Cyclohexa-1,5-dienecarbonyl-CoA hydratase
IPR017633 Family Benzoyl-CoA-dihydrodiol lyase
IPR017613 Family 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase
IPR011968 Family Phenylacetate degradation probable enoyl-CoA hydratase PaaB

0 Contains

1 Cross References

Identifier
PF00378

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0003824 IPR001753
GO:0008152 IPR001753

2 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR001753
GO:0008152 IPR001753

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
96713 PAC:15410032 Selaginella moellendorffii 357  
413420 D8RPE4 PAC:15414498 Selaginella moellendorffii 365  
138809 PAC:15403483 Selaginella moellendorffii 357  
109806 D8S6B8 PAC:15407128 Selaginella moellendorffii 316  
421553 D8SFM4 PAC:15416550 Selaginella moellendorffii 287  
439227 D8R2V8 PAC:15422416 Selaginella moellendorffii 243  
439712 D8R5A7 PAC:15403851 Selaginella moellendorffii 732  
86180 D8R690 PAC:15420683 Selaginella moellendorffii 363  
evm.model.supercontig_1.378 PAC:16404319 Carica papaya 244  
evm.model.supercontig_127.34 PAC:16407397 Carica papaya 502  
evm.model.supercontig_218.2 PAC:16413825 Carica papaya 400  
evm.model.supercontig_23.137 PAC:16414185 Carica papaya 383  
evm.model.supercontig_44.86 PAC:16420229 Carica papaya 239  
evm.model.supercontig_473.2 PAC:16420712 Carica papaya 356  
29709.m001229 B9SKJ5 PAC:16806445 Ricinus communis 384  
29726.m004067 B9RT76 PAC:16806778 Ricinus communis 541  
29726.m004068 B9RT77 PAC:16806779 Ricinus communis 148  
29734.m000416 B9SKX9 PAC:16807105 Ricinus communis 389  
29848.m004538 B9RNV7 PAC:16811194 Ricinus communis 406  
29848.m004692 B9RPB0 PAC:16811347 Ricinus communis 416  
29929.m004598 B9RM93 PAC:16813837 Ricinus communis 275  
29932.m000622 B9SKV9 PAC:16814107 Ricinus communis 253  
29989.m000433 B9SR76 PAC:16815210 Ricinus communis 246  
30075.m001196 B9SAY4 PAC:16817049 Ricinus communis 128  
30101.m000373 B9SXD3 PAC:16817773 Ricinus communis 403  
30174.m008800 B9RD44 PAC:16822445 Ricinus communis 415  
31967.m000029 B9TE90 PAC:16825257 Ricinus communis 265  
32596.m000017 PAC:16825487 Ricinus communis 325  
60046.m000015 B9TMW8 PAC:16829316 Ricinus communis 243  
29585.m000591 B9SR30 PAC:16803155 Ricinus communis 240  

13 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1958319
            9739087
            10769118
            11738050
            12445775
            15138275
            16131752
            11263873
            16096274
            17198383
            8679561
            11551212
            5229654