| Type: | Family | Name: | S-phase kinase-associated protein 1-like |
| Description: | This entry includes SKP1 and SKP1-like proteins. S-phase kinase-associated protein 1 (SKP1) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex []. It was found to bind several F-box containing proteins (e.g., Cdc4, Skp2, cyclin F) and to be involved in the ubiquitin protein degradation pathway. A yeast homologue of SKP1 (P52286) was identified in the centromere bound kinetochore complex [] and is also involved in the ubiquitin pathway []. In Dictyostelium discoideum(Slime mold) FP21 was shown to be glycosylated in the cytosol and has homology to SKP1 [].SKP1-like proteins in this entry include transcription elongation factor B polypeptide 1 (TCEB1, also known as RNA polymerase II transcription factor SIII subunit C) from animals and elongin-C from yeasts. TCEB1 is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites []. It forms a complex with SIII regulatory subunits B, which serves as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes []. Elongin-C forms a complex with Cul3 that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis []. | Short Name: | SKP1-like |
