| Type: | Domain | Name: | Myosin-like IQ motif-containing domain |
| Description: | This entry represents a subdomain that spans the IQ motif () of myosins, Ras GTPase-activating-like protein IQGAP1 and abnormal spindle protein (Asp). The IQ motif is an extremely basic unit of about 23 amino acids, whose conserved core usually fits the consensus A-x(3)-I-Q-x(2)-F-R-x(4)-K-K. The IQ motif, which can be present in one or more copies, serves as a binding site for different EF-hand proteins including the essential and regulatory myosin light chains, calmodulin (CaM), and CaM-like proteins [, ]. Many IQ motifs are protein kinase C (PKC) phosphorylation sites [, ]. Resolution of the 3D structure of scallop myosin has shown that the IQ motif forms a basic amphipathic helix []. | Short Name: | Myosin-like_IQ_dom |
