Protein Domain : IPR008242

Type:  Family Name:  Bifunctional P-protein, chorismate mutase/prephenate dehydratase
Description:  The bifunctional P-protein, which plays a central role in phenylalanine biosynthesis, contains two catalytic domains (chorismate mutase and prephenate dehydratase) and a regulatory domain (ACT). It is part of the shikimate pathway, which is present only in bacteria, fungi, and plants.Chorismate mutase (CM; ) catalyses the rearrangement of chorismate to prephenate, the reaction at the branch point of the biosynthetic pathway leading to the three aromatic amino acids, phenylalanine, tryptophan and tyrosine (chorismic acid is the last common intermediate, and CM leads to the L-phenylalanine/L-tyrosine branch). The chorismate mutase domain of this protein belongs to the AroQ class (prokaryotic type) [] and has an all-helical structure. There are stand-alone versions of this domain, as well as fusions to other catalytic domains (such as prephenate dehydrogenase or DAHP synthase), or to regulatory domains.Prephenate dehydratase (PDT; ) converts prephenate to phenylpyruvate. In the Escherichia coli P-protein, the ACT domain has been shown to be essential for phenylalanine-mediated feedback inhibition and ligand binding []. It is a ligand-binding regulatory domain found primarily in enzymes and regulators of amino acid and purine metabolism []. Short Name:  Chor_mutase/pphenate_deHydtase
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0 Child Features

6 Contains

DB identifier Type Name
IPR020822 Domain Chorismate mutase, type II
IPR002912 Domain ACT domain
IPR001086 Domain Prephenate dehydratase
IPR010952 Domain Chorismate mutase, gammaproteobacteria
IPR018528 Conserved_site Prephenate dehydratase, conserved site
IPR010957 Domain Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain

1 Cross References

Identifier
PIRSF001500

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004106 IPR008242
GO:0004664 IPR008242
GO:0009094 IPR008242
GO:0005737 IPR008242

4 Ontology Annotations

GO Term Gene Name
GO:0004106 IPR008242
GO:0004664 IPR008242
GO:0009094 IPR008242
GO:0005737 IPR008242

0 Parent Features

188 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
95583 D8RKK2 PAC:15405654 Selaginella moellendorffii 347  
142600 D8R0E4 PAC:15414134 Selaginella moellendorffii 391  
Cucsa.045180.1 PAC:16953326 Cucumis sativus 305  
Cucsa.200050.1 PAC:16968733 Cucumis sativus 294  
orange1.1g023305m PAC:18119413 Citrus sinensis 284  
Lus10031547 PAC:23155782 Linum usitatissimum 367  
Lus10015130 PAC:23149568 Linum usitatissimum 367  
Gorai.006G121300.6 A0A0D2NR01 PAC:26831187 Gossypium raimondii 309  
Gorai.006G109800.2 A0A0D2Q7K2 PAC:26833182 Gossypium raimondii 301  
Gorai.006G121300.5 A0A0D2NR01 PAC:26831186 Gossypium raimondii 309  
Gorai.006G121300.8 A0A0D2SWA1 PAC:26831189 Gossypium raimondii 309  
Gorai.006G121300.7 A0A0D2NR01 PAC:26831188 Gossypium raimondii 309  
12515 I0Z6Q1 PAC:27393195 Coccomyxa subellipsoidea C-169 318  
212169 PAC:27342749 Micromonas pusilla CCMP1545 329  
93192 C1FED1 PAC:27399053 Micromonas sp RCC299 324  
13638 A4RQP2 PAC:27417555 Ostreococcus lucimarinus 348  
Thecc1EG011909t2 A0A061EIW8 PAC:27462036 Theobroma cacao 308  
Araha.45788s0001.1.p PAC:28857293 Arabidopsis halleri 298  
Brara.C03221.1.p A0A398A3P6 PAC:30616667 Brassica rapa FPsc 351  
Medtr2g088130.2 G7ITX1 PAC:31064411 Medicago truncatula 325  
Spipo6G0023700 PAC:31505768 Spirodela polyrhiza 361  
Spipo1G0097800 PAC:31520899 Spirodela polyrhiza 339  
Traes_2AS_4FE661410.1 PAC:31786861 Triticum aestivum 297  
Traes_2BS_7E7E33943.1 PAC:31837457 Triticum aestivum 297  
Traes_2BS_7E7E33943.2 PAC:31837456 Triticum aestivum 297  
Traes_4AS_4B1A64B8F.3 PAC:31999471 Triticum aestivum 296  
Traes_4AS_A0CE022D5.5 PAC:31942708 Triticum aestivum 297  
Traes_4BL_7A3CDCBF0.3 PAC:31800698 Triticum aestivum 293  
Traes_4BL_7A3CDCBF0.2 PAC:31800697 Triticum aestivum 296  
Traes_4BL_7A3CDCBF0.1 PAC:31800696 Triticum aestivum 296  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10222208
            11528003
            10493788