Protein Domain : IPR001464

Type:  Family Name:  Annexin
Description:  The annexins (or lipocortins) are a family of proteins that bind to phospholipids in a calcium-dependent manner []. They are distributed ubiquitously in different tissues and cell types of higher and lower eukaryotes, including mammals, fish, birds, Drosophila melanogaster(Fruit fly), Xenopus laevis(African clawed frog), Caenorhabditis elegans, Dictyostelium discoideum(Slime mold) and Neurospora crassa[, ]. Annexins are absent from yeasts and prokaryotes []. The plant annexins are somewhat distinct from those found in other taxa [].Most eukaryotic species have 1-20 annexin (ANX) genes. All annexins share a core domain made up of four similar repeats, each approximately 70 amino acids long []. Each individual annexin repeat (sometimes referred to as endonexin folds) is folded into five alpha-helices, and in turn are wound into a right-handed super-helix; they usually contain a characteristic 'type 2' motif for binding calcium ions with the sequence 'GxGT-[38 residues]-D/E'. Animal and fungal annexins also have variable amino-terminal domains. The core domains of most vertebrate annexins have been analysed by X-ray crystallography, revealing conservation of their secondary and tertiary structures despite only 45-55% amino-acid identity among individual members. The four repeats pack into a structure that resembles a flattened disc, with a slightly convex surface on which the Ca 2+ -binding loops are located and a concave surface at which the amino and carboxyl termini come into close apposition.Annexins are traditionally thought of as calcium-dependent phospholipid-binding proteins, but recent work suggests a more complex set of functions. The famiy has been linked with inhibition of phospholipase activity, exocytosis and endoctyosis, signal transduction, organisation of the extracellular matrix, resistance to reactive oxygen species and DNA replication []. Short Name:  Annexin
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16 Child Features

DB identifier Type Name
IPR009118 Family Annexin, plant
IPR013286 Family Annexin, type VII
IPR002388 Family Annexin, type I
IPR002389 Family Annexin, type II
IPR002390 Family Annexin, type III
IPR002391 Family Annexin, type IV
IPR002392 Family Annexin, type V
IPR002393 Family Annexin, type VI
IPR008088 Family Alpha giardin
IPR008156 Family Annexin, type X
IPR008157 Family Annexin, type XI
IPR009115 Family Annexin, type VIII
IPR009116 Family Annexin, type XXXI
IPR009117 Family Annexin, type fungal XIV
IPR009166 Family Annexin, type XIII
IPR015473 Family Annexin V

2 Contains

DB identifier Type Name
IPR018502 Repeat Annexin repeat
IPR018252 Conserved_site Annexin repeat, conserved site

1 Cross References

Identifier
PR00196

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0005509 IPR001464
GO:0005544 IPR001464

2 Ontology Annotations

GO Term Gene Name
GO:0005509 IPR001464
GO:0005544 IPR001464

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
94768 D8RJM1 PAC:15404179 Selaginella moellendorffii 315  
227533 D8R2M8 PAC:15405463 Selaginella moellendorffii 315  
167346 D8R2M4 PAC:15418525 Selaginella moellendorffii 315  
evm.TU.contig_36671.1 PAC:16430896 Carica papaya 315  
evm.model.supercontig_157.68 PAC:16409858 Carica papaya 315  
evm.model.supercontig_161.4 PAC:16410210 Carica papaya 325  
evm.model.supercontig_197.1 PAC:16412334 Carica papaya 293  
evm.model.supercontig_197.2 PAC:16412345 Carica papaya 318  
evm.model.supercontig_2.129 PAC:16412485 Carica papaya 316  
evm.model.supercontig_213.13 PAC:16413698 Carica papaya 316  
evm.model.supercontig_3.340 PAC:16416636 Carica papaya 314  
evm.model.supercontig_42.66 PAC:16419828 Carica papaya 137  
evm.model.supercontig_42.84 PAC:16419848 Carica papaya 255  
evm.model.supercontig_4842.1 PAC:16420980 Carica papaya 236  
29811.m000529 B9SM17 PAC:16809378 Ricinus communis 318  
29908.m006020 B9RJJ1 PAC:16812843 Ricinus communis 315  
29968.m000666 B9SNI5 PAC:16814650 Ricinus communis 155  
30072.m000977 B9SIA1 PAC:16816767 Ricinus communis 325  
30131.m007217 B9RGC8 PAC:16819038 Ricinus communis 314  
30131.m007218 B9RGC9 PAC:16819039 Ricinus communis 315  
30131.m007219 B9RGD0 PAC:16819040 Ricinus communis 319  
28281.m000366 B9SZ35 PAC:16800472 Ricinus communis 181  
28342.m000016 B9T8F3 PAC:16800707 Ricinus communis 248  
Cucsa.340270.1 PAC:16979026 Cucumis sativus 318  
Cucsa.138380.1 PAC:16963249 Cucumis sativus 321  
Cucsa.217870.1 A0A0A0K5Y8 PAC:16969596 Cucumis sativus 314  
Cucsa.234800.1 PAC:16970390 Cucumis sativus 316  
Cucsa.234800.2 PAC:16970391 Cucumis sativus 257  
Cucsa.234800.3 PAC:16970392 Cucumis sativus 236  
Cucsa.234810.1 PAC:16970393 Cucumis sativus 293  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1646719
            9797403
            9165068
            15059252