| Type: | Family | Name: | E2F Family |
| Description: | The E2F family of transcription factors plays a crucial role in the control of cell cycle and action of tumour suppressor proteins and is also a target of the transforming proteins of small DNA tumour viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA-binding domain, a dimerisation domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumour suppressor protein association domain which is embedded within the transactivation domain []. | Short Name: | E2F |
