4 GO Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR013498 |
| GO:0003916 | IPR013498 |
| GO:0006265 | IPR013498 |
| GO:0005694 | IPR013498 |
4 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR013498 |
| GO:0003916 | IPR013498 |
| GO:0006265 | IPR013498 |
| GO:0005694 | IPR013498 |
| Type: | Domain | Name: | DNA topoisomerase, type IA, zn finger |
| Description: | DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type I topoisomerases are ATP-independent enzymes (except for reverse gyrase), and can be subdivided according to their structure and reaction mechanisms: type IA (bacterial and archaeal topoisomerase I, topoisomerase III and reverse gyrase) and type IB (eukaryotic topoisomerase I and topoisomerase V). These enzymes are primarily responsible for relaxing positively and/or negatively supercoiled DNA, except for reverse gyrase, which can introduce positive supercoils into DNA. This entry represents the zinc-finger domain found in type IA topoisomerases, including bacterial and archaeal topoisomerase I and III enzymes, and in eukaryotic topoisomerase III enzymes. Escherichia colitopoisomerase I proteins contain five copies of a zinc-ribbon-like domain at their C terminus, two of which have lost their cysteine residues and are therefore probably not able to bind zinc []. This domain is still considered to be a member of the zinc-ribbon superfamily despite not being able to bind zinc. | Short Name: | Topo_IA_Znf |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR013498 |
| GO:0003916 | IPR013498 |
| GO:0006265 | IPR013498 |
| GO:0005694 | IPR013498 |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR013498 |
| GO:0003916 | IPR013498 |
| GO:0006265 | IPR013498 |
| GO:0005694 | IPR013498 |
