Protein Domain : IPR004706

Type:  Family Name:  Arsenical-resistance protein Acr3
Description:  Members of the ACR3 family of arsenite (As(III)) permeases confer resistance to arsenic by extrusion from cells []. They exist in prokaryotes and eukaryotes (lower plants and fungi) [, ]. The ACR3 permeases have ten-transmembrane span topology []. Corynebacterium glutamicum has three Acr3 proteins, CgAcr3-1, CgAcr3-2, and CgAcr3-3. CgAcr3-1 is thought to be an antiporter that catalyses arsenite-proton exchange [].The Shewanella oneidensis Acr3 is not able to transport As(III) and confers resistance only to arsenate (As(V)) [], whereas the Acr3 orthologue from Synechocystis mediates tolerance to As(III), As(V) and antimonite (Sb(III)) [].In budding yeast, overexpression of the Acr3 gene confers an arsenite- but not an arsenate-resistance phenotype []. Saccharomyces cerevisiae Acr3 is a plasma membrane metalloid/H+ antiporter that transports arsenite and antimonite []. Short Name:  Arsenical-R_Acr3

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PTHR10361:SF31
PIRSF005508
TIGR00832

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0015103 IPR004706
GO:0015297 IPR004706
GO:0016021 IPR004706

3 Ontology Annotations

GO Term Gene Name
GO:0015103 IPR004706
GO:0015297 IPR004706
GO:0016021 IPR004706

1 Parent Features

DB identifier Type Name
IPR002657 Family Bile acid:sodium symporter/arsenical resistance protein Acr3

20 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
411467 PAC:15408588 Selaginella moellendorffii 452  
34042.m000025 B9TDE3 PAC:16826079 Ricinus communis 348  
14170 I0Z1F3 PAC:27387300 Coccomyxa subellipsoidea C-169 360  
Sphfalx0018s0220.1.p PAC:32610926 Sphagnum fallax 458  
Pp3c23_18240V3.1.p A0A2K1IJV6 PAC:32950191 Physcomitrium patens 477  
Pp3c23_18240V3.2.p A0A2K1IJV6 PAC:32950192 Physcomitrium patens 477  
Mapoly0171s0014.1.p A0A2R6W2X4 PAC:33027778 Marchantia polymorpha 457  
Cz06g10050.t1 PAC:38248782 Chromochloris zofingiensis 507  
Cz09g00060.t1 PAC:38238801 Chromochloris zofingiensis 505  
Cz17g00070.t1 PAC:38247696 Chromochloris zofingiensis 497  
Bobra.55_2s0044.1.p PAC:40710133 Botryococcus braunii 452  
Bobra.55_2s0044.2.p PAC:40710134 Botryococcus braunii 323  
Cocit.L4251.1.p PAC:41039954 Corymbia citriodora 407  
Sphmag05G047200.1.p PAC:41908591 Sphagnum magellanicum 454  
Sphfalx05G040600.1.p PAC:41963433 Sphagnum fallax 458  
CepurR40.10G102300.1.p PAC:42999169 Ceratodon purpureus R40 459  
CepurGG1.10G100100.1.p PAC:43060262 Ceratodon purpureus GG1 459  
Thupl.29379155s0008.1.p PAC:44946504 Thuja plicata 461  
Ceric.37G003400.1.p PAC:50616388 Ceratopteris richardii 409  
Ceric.37G003400.2.p PAC:50616389 Ceratopteris richardii 393  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9234670
            19494117
            22102279
            18088595
            20530755
            24291645
            19039703
            12949088
            21447319