Protein Domain : IPR007369

Type:  Family Name:  Peptidase A22B, signal peptide peptidase
Description:  This group of sequences contain aspartic endopeptidases belong to MEROPS peptidase family A22 (presenilin family, clan AD): subfamily A22B.The peptidases were originally classified by hierarchical homology to the most conserved member - IMPAS 1. They are also known as signal peptide peptidase (SPP) []. They belong to the I-CliP family of peptidases. SPP cleaves cleaves remnant signal peptides left behind in the membrane by the action of signal peptidase and also plays key roles in immune surveillance and the maturation of certain viral proteins []. SPPs do not require cofactors as demonstrated by expression in bacteria and purification of a proteolytically active form. The C-terminal region defines the functional domain, which is in itself sufficient for proteolytic activity []. Short Name:  Peptidase_A22B_SPP
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR12174
PF04258

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004190 IPR007369
GO:0016021 IPR007369

2 Ontology Annotations

GO Term Gene Name
GO:0004190 IPR007369
GO:0016021 IPR007369

1 Parent Features

DB identifier Type Name
IPR006639 Family Presenilin/signal peptide peptidase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
93092 D8RHI9 PAC:15418398 Selaginella moellendorffii 549  
271219 D8S0R8 PAC:15421512 Selaginella moellendorffii 346  
179700 D8SHA7 PAC:15412223 Selaginella moellendorffii 552  
117257 D8SHE9 PAC:15404021 Selaginella moellendorffii 168  
427022 D8SY94 PAC:15407816 Selaginella moellendorffii 360  
evm.TU.contig_45617.1 PAC:16432202 Carica papaya 37  
evm.model.supercontig_107.68 PAC:16405374 Carica papaya 340  
evm.model.supercontig_11.10 PAC:16405585 Carica papaya 536  
evm.model.supercontig_50.134 PAC:16421593 Carica papaya 234  
evm.model.supercontig_74.6 PAC:16425752 Carica papaya 544  
evm.model.supercontig_84.1 PAC:16427259 Carica papaya 245  
29811.m000537 B9SM25 PAC:16809386 Ricinus communis 341  
29888.m000320 B9SUL7 PAC:16812174 Ricinus communis 535  
30169.m006252 B9RIX2 PAC:16821055 Ricinus communis 371  
30174.m008612 B9RDT1 PAC:16822258 Ricinus communis 538  
30190.m011228 B9RCD0 PAC:16823585 Ricinus communis 542  
Cucsa.365670.1 PAC:16981449 Cucumis sativus 541  
Cucsa.107890.3 PAC:16959646 Cucumis sativus 369  
Cucsa.107890.4 PAC:16959647 Cucumis sativus 330  
Cucsa.107890.1 PAC:16959644 Cucumis sativus 369  
Cucsa.107890.2 PAC:16959645 Cucumis sativus 369  
Cucsa.135560.1 A0A0A0KB96 PAC:16962954 Cucumis sativus 539  
Cucsa.135560.2 PAC:16962955 Cucumis sativus 451  
Cucsa.135560.3 PAC:16962956 Cucumis sativus 445  
Cucsa.303240.1 A0A0A0KKI6 PAC:16975880 Cucumis sativus 545  
Cucsa.303240.2 PAC:16975881 Cucumis sativus 475  
Cucsa.311390.2 A0A0A0LGU3 PAC:16976672 Cucumis sativus 341  
Cucsa.311390.1 A0A0A0LGU3 PAC:16976671 Cucumis sativus 341  
Cucsa.311390.3 PAC:16976673 Cucumis sativus 340  
orange1.1g013003m A0A067GLR1 PAC:18118986 Citrus sinensis 451  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14741365
            12966028
            17517891