Protein Domain : IPR000116

Type:  Family Name:  High mobility group protein HMGA
Description:  This entry represents the HMGA family, whose members contain DNA-binding domains, also known as AT hooks due to their ability to interact with the narrow minor groove of AT-rich DNA sequences. They play an important role in chromatin organisation [].The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family []. Short Name:  HMGA
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2 Child Features

DB identifier Type Name
IPR031059 Family High mobility group protein HMGA, plant
IPR031079 Family High mobility group protein HMGA1, mammal

2 Contains

DB identifier Type Name
IPR017956 Conserved_site AT hook, DNA-binding motif
IPR000637 Conserved_site HMG-I/HMG-Y, DNA-binding, conserved site

1 Cross References

Identifier
PR00930

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR000116
GO:0006355 IPR000116
GO:0000785 IPR000116
GO:0005634 IPR000116

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR000116
GO:0006355 IPR000116
GO:0000785 IPR000116
GO:0005634 IPR000116

1 Parent Features

DB identifier Type Name
IPR020478 Family AT hook-like

600 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
441144 D8RGW2 PAC:15405523 Selaginella moellendorffii 1340  
evm.model.supercontig_116.54 PAC:16406312 Carica papaya 179  
evm.model.supercontig_844.1 PAC:16427392 Carica papaya 188  
29005.m000251 B9T0Z4 PAC:16802145 Ricinus communis 166  
28779.m000138 B9T5M6 PAC:16801689 Ricinus communis 847  
29692.m000530 B9SP65 PAC:16805916 Ricinus communis 199  
Cucsa.031270.1 A0A0A0LCH9 PAC:16952273 Cucumis sativus 180  
Cucsa.280260.1 A0A0A0KPG4 PAC:16974195 Cucumis sativus 186  
orange1.1g028369m A0A067FB09 PAC:18095796 Citrus sinensis 210  
AT1G14900.1 Q43386 PAC:19650804 Arabidopsis thaliana 204  
Thhalv10008756m V4L6C9 PAC:20186260 Eutrema salsugineum 215  
Thhalv10004909m V4KPD9 PAC:20198750 Eutrema salsugineum 213  
Thhalv10011757m V4KHK5 PAC:20184983 Eutrema salsugineum 226  
Ciclev10012880m V4SSW7 PAC:20797753 Citrus clementina 184  
Ciclev10016374m V4UBB8 PAC:20816236 Citrus clementina 251  
Lus10002284 PAC:23171937 Linum usitatissimum 181  
Lus10004056 PAC:23156736 Linum usitatissimum 190  
Potri.004G087500.2 PAC:26989974 Populus trichocarpa 185  
Potri.004G087500.3 B9H3A3 PAC:26989973 Populus trichocarpa 189  
Potri.004G087500.1 B9H3A3 PAC:26989972 Populus trichocarpa 189  
Potri.017G129400.1 U5FJD9 PAC:26984538 Populus trichocarpa 190  
Potri.010G109600.1 A9PDE5 PAC:26978408 Populus trichocarpa 215  
Potri.008G132400.1 B9HJD9 PAC:27038597 Populus trichocarpa 207  
Potri.008G200900.5 PAC:27039380 Populus trichocarpa 909  
Potri.008G200900.3 PAC:27039379 Populus trichocarpa 909  
Potri.008G200900.4 A0A2K1ZKG8 PAC:27039378 Populus trichocarpa 931  
Potri.008G200900.1 A0A2K1ZKG8 PAC:27039377 Populus trichocarpa 931  
Gorai.001G088600.3 A0A0D2PWN2 PAC:26821275 Gossypium raimondii 179  
Gorai.001G088600.2 A0A0D2PWN2 PAC:26821276 Gossypium raimondii 179  
Gorai.001G088600.1 A0A0D2PWN2 PAC:26821277 Gossypium raimondii 179  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            25281808
            14645522