Protein Domain : IPR001791

Type:  Domain Name:  Laminin G domain
Description:  Laminins are large heterotrimeric glycoproteins involved in basement membrane function []. The Laminin G or LNS domain (for Laminin-alpha, Neurexin and Sex hormone-binding globulin) is an around 180 amino acid long domain found in a large and diverse set of extracellular proteins [, ]. The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. The C terminus of the laminin alpha chain contains a tandem repeat of five laminin G domains, which are critical for heparin-binding and cell attachment activity []. Laminin alpha4 is distributed in a variety of tissues including peripheral nerves, dorsal root ganglion, skeletal muscle and capillaries; in the neuromuscular junction, it is required for synaptic specialisation []. The structure of the laminin-G domain has been predicted to resemble that of pentraxin [].Laminin G domains can vary in their function, and a variety of binding functions have been ascribed to different LamG modules. For example, the laminin alpha1 and alpha2 chains each have five C-teminal laminin G domains, where only domains LG4 and LG5 contain binding sites for heparin, sulphatides and the cell surface receptor dystroglycan []. Laminin G-containing proteins appear to have a wide variety of roles in cell adhesion, signalling, migration, assembly and differentiation. Proteins with laminin-G domains include:Laminin.Merosin.Agrin.Neurexins.Vitamin K dependent protein S.Sex steroid binding protein SBP/SHBG.Drosophila proteins Slit, Crumbs, Fat.several proteoglycan precursors. Short Name:  Laminin_G
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0 Child Features

0 Contains

5 Cross Referencess

Identifier
PF00054
PF02210
PS50025
SM00210
SM00282

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR013320 Domain Concanavalin A-like lectin/glucanase domain

10 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
448687 D8T9D2 PAC:15407529 Selaginella moellendorffii 954  
421556 D8SFM7 PAC:15416556 Selaginella moellendorffii 861  
445106 D8SFM0 PAC:15417183 Selaginella moellendorffii 959  
407389 D8R5G0 PAC:15418302 Selaginella moellendorffii 874  
gene26698-v2.0.a2-hybrid.t1 PAC:40677626 Fragaria vesca 677  
maker-Fvb7-2-augustus-gene-296.57-mRNA-1 PAC:50494415 Fragaria x ananassa 679  
maker-Fvb7-4-augustus-gene-68.44-mRNA-1 PAC:50542576 Fragaria x ananassa 668  
maker-Fvb7-1-snap-gene-248.42-mRNA-1 PAC:50488334 Fragaria x ananassa 502  
snap_masked-Fvb7-3-processed-gene-76.25-mRNA-1 PAC:50480673 Fragaria x ananassa 407  
FvH4_7g21531.t1 PAC:50674853 Fragaria vesca 677  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1975589
            9480764
            10747011
            15823034
            15037599