Protein Domain : IPR015712

Type:  Family Name:  DNA-directed RNA polymerase, subunit 2
Description:  DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. Most RNA polymerases are multimericenzymes and are composed of a variable number of subunits. The core RNA polymerase complex consists of five subunits (two alpha, one beta, one beta-prime and one omega) and is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with the core RNA polymerase complex to form a holoenzyme []. The core RNA polymerase complex forms a "crab claw"-like structure with an internal channel running along the full length []. The key functional sites of the enzyme, as defined by mutational and cross-linking analysis, are located on the inner wall of this channel.RNA synthesis follows after the attachment of RNA polymerase to a specific site, the promoter, on the template DNA strand. The RNA synthesis process continues until a termination sequence is reached. The RNA product, which is synthesised in the 5' to 3'direction, is known as the primary transcript. Eukaryotic nuclei contain three distinct types of RNA polymerases that differ in the RNA they synthesise:RNA polymerase I: located in the nucleoli, synthesises precursors of most ribosomal RNAs.RNA polymerase II: occurs in the nucleoplasm, synthesises mRNA precursors. RNA polymerase III: also occurs in the nucleoplasm, synthesises the precursors of 5S ribosomal RNA, the tRNAs, and a variety of other small nuclear and cytosolic RNAs. Eukaryotic cells are also known to contain separate mitochondrial and chloroplast RNA polymerases. Eukaryotic RNA polymerases, whose molecular masses vary in size from 500 to 700 kDa, contain two non-identical large (>100 kDa) subunits and an array of up to 12 different small (less than 50 kDa) subunits.This protein appears to be specific to DNA-directed RNA polymerases, subunit 2. Short Name:  DNA-dir_RNA_pol_su2
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1 Child Features

DB identifier Type Name
IPR010243 Family DNA-directed RNA polymerase, beta subunit

9 Contains

DB identifier Type Name
IPR007120 Domain DNA-directed RNA polymerase, subunit 2, domain 6
IPR007647 Domain RNA polymerase Rpb2, domain 5
IPR007641 Domain RNA polymerase Rpb2, domain 7
IPR007646 Domain RNA polymerase Rpb2, domain 4
IPR007645 Domain RNA polymerase Rpb2, domain 3
IPR009674 Domain RNA polymerase I, Rpa2 specific
IPR014724 Domain RNA polymerase Rpb2, OB-fold
IPR019462 Domain DNA-directed RNA polymerase, beta subunit, external 1 domain
IPR007121 Conserved_site RNA polymerase, beta subunit, conserved site

1 Cross References

Identifier
PTHR20856

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003899 IPR015712
GO:0032549 IPR015712
GO:0006351 IPR015712

3 Ontology Annotations

GO Term Gene Name
GO:0003899 IPR015712
GO:0032549 IPR015712
GO:0006351 IPR015712

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92553 PAC:15419202 Selaginella moellendorffii 617  
236845 PAC:15412131 Selaginella moellendorffii 1069  
148107 D8RLN5 PAC:15405344 Selaginella moellendorffii 1178  
101823 D8RUX1 PAC:15406172 Selaginella moellendorffii 692  
405033 D8QY62 PAC:15410045 Selaginella moellendorffii 1126  
443461 D8S1N7 PAC:15413877 Selaginella moellendorffii 1386  
118653 D8SKA2 PAC:15410128 Selaginella moellendorffii 762  
237023 PAC:15408828 Selaginella moellendorffii 1069  
139194 PAC:15401304 Selaginella moellendorffii 390  
139200 PAC:15401925 Selaginella moellendorffii 213  
237024 PAC:15408829 Selaginella moellendorffii 1031  
237022 PAC:15408826 Selaginella moellendorffii 1069  
evm.TU.contig_36967.1 PAC:16430959 Carica papaya 131  
evm.TU.contig_45563.1 PAC:16432196 Carica papaya 105  
evm.model.supercontig_127.33 PAC:16407396 Carica papaya 1117  
evm.model.supercontig_169.36 PAC:16410558 Carica papaya 511  
evm.model.supercontig_169.38 PAC:16410560 Carica papaya 366  
evm.model.supercontig_17.37 PAC:16410758 Carica papaya 209  
evm.model.supercontig_17.36 PAC:16410757 Carica papaya 111  
evm.model.supercontig_17.35 PAC:16410756 Carica papaya 386  
evm.model.supercontig_27.44 PAC:16415664 Carica papaya 1049  
evm.model.supercontig_3766.2 PAC:16418829 Carica papaya 93  
29848.m004540 B9RNV9 PAC:16811196 Ricinus communis 1203  
29851.m002412 B9RZ91 PAC:16811439 Ricinus communis 1194  
30022.m000379 B9SF66 PAC:16815718 Ricinus communis 53  
30040.m000275 B9SVH7 PAC:16816021 Ricinus communis 1159  
30174.m008868 B9RDB2 PAC:16822513 Ricinus communis 173  
29686.m000857 B9SHS2 PAC:16805768 Ricinus communis 1139  
Cucsa.355360.1 PAC:16980185 Cucumis sativus 96  
Cucsa.046200.1 PAC:16953485 Cucumis sativus 1199  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3052291
            10499798