| Type: | Domain | Name: | Dilute domain |
| Description: | The myosin superfamily consists of at least 15 distinct classes of presumed actin-based molecular motors. All members of the superfamily share a similarmotor domain and a tail portion which is diagnostic of the class [].Class V myosins are actin-based molecular motors that function in relatively long-range movements of many intracellular cargoes including organelles,membrane vesicles, and mRNA []. These motors are ubiquitously found in alleukaryotes. Class V myosins are characterised by the presence of a conserved globular domain at the C terminus of the tail portion: the dilute domain []. Myosin V moves via attachment of its amino terminal head (motor) domain to actin cables; its carboxyl terminal dilute domain anchors it to cargoes via attachments to organelle-specific receptors [, ].The dilute domain is also found in the afadin family. Afadins are nectin and actin filament-binding proteins that connect nectin to the actin cytoskeleton[]. | Short Name: | Dilute_dom |
