Protein Domain : IPR001804

Type:  Family Name:  Isocitrate and isopropylmalate dehydrogenases family
Description:  The isocitrate and isopropylmalate dehydrogenases family includes isocitrate dehydrogenase (IDH), 3-isopropylmalate dehydrogenase (IMDH) and tartrate dehydrogenase.IDH is an important enzyme of carbohydrate metabolism which catalyses the oxidative decarboxylation of isocitrate into alpha-ketoglutarate [, ]. IDH is either dependent on NAD+() or on NADP+(). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD+-dependent, the other NADP+-dependent), while the third one (also NADP+-dependent) is cytoplasmic. In Escherichia coli, the activity of a NADP+-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.IMDH () catalyses the third step in the biosynthesis of leucine in bacteria and fungi, the oxidative decarboxylation of 3-isopropylmalate into 2-oxo-4-methylvalerate [, ]. Tartrate dehydrogenase () shows strong homology to prokaryotic isopropylmalate dehydrogenases and, to a lesser extent, isocitrate dehydrogenase []. It catalyses the reduction of tartrate to oxaloglycolate []. Short Name:  Isocitrate/isopropylmalate_DH
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7 Child Features

DB identifier Type Name
IPR004429 Family Isopropylmalate dehydrogenase
IPR004434 Family Isocitrate dehydrogenase NAD-dependent
IPR011829 Family Tartrate dehydrogenase
IPR004439 Family Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic
IPR014273 Family Isocitrate dehydrogenase, alphaproteobacteria-type
IPR011828 Family Isopropylmalate/isohomocitrate dehydrogenase
IPR023698 Family 3-isopropylmalate dehydrogenase

1 Contains

DB identifier Type Name
IPR019818 Conserved_site Isocitrate/isopropylmalate dehydrogenase, conserved site

1 Cross References

Identifier
PTHR11835

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0000287 IPR001804
GO:0016616 IPR001804
GO:0051287 IPR001804
GO:0055114 IPR001804

4 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR001804
GO:0016616 IPR001804
GO:0051287 IPR001804
GO:0055114 IPR001804

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231507 D8RG96 PAC:15417437 Selaginella moellendorffii 342  
111515 D8S8Y1 PAC:15411175 Selaginella moellendorffii 401  
233612 D8SC18 PAC:15401701 Selaginella moellendorffii 330  
evm.model.supercontig_20.195 PAC:16412998 Carica papaya 373  
evm.model.supercontig_52.151 PAC:16422011 Carica papaya 349  
evm.model.supercontig_92.119 PAC:16428577 Carica papaya 393  
30078.m002318 B9S0K1 PAC:16817429 Ricinus communis 364  
29628.m000748 B9SRZ2 PAC:16803891 Ricinus communis 372  
27446.m000482 B9SWT3 PAC:16798342 Ricinus communis 406  
28506.m000056 B9T9K2 PAC:16800991 Ricinus communis 359  
Cucsa.044200.1 A0A0A0KMQ6 PAC:16953164 Cucumis sativus 381  
Cucsa.044200.2 PAC:16953165 Cucumis sativus 377  
Cucsa.096160.1 A0A0A0KTH3 PAC:16957991 Cucumis sativus 405  
Cucsa.096160.2 PAC:16957992 Cucumis sativus 378  
Cucsa.096160.3 PAC:16957993 Cucumis sativus 325  
Cucsa.124520.1 A0A0A0KF41 PAC:16961721 Cucumis sativus 372  
Cucsa.124520.2 PAC:16961722 Cucumis sativus 337  
Cucsa.124520.3 PAC:16961723 Cucumis sativus 285  
Cucsa.119810.1 PAC:16961030 Cucumis sativus 339  
Cucsa.226670.1 PAC:16969985 Cucumis sativus 165  
orange1.1g034454m A0A067G7Q1 PAC:18098501 Citrus sinensis 94  
orange1.1g019198m A0A067FXX5 PAC:18099306 Citrus sinensis 344  
orange1.1g018224m A0A067FLS4 PAC:18099305 Citrus sinensis 359  
orange1.1g017413m A0A067E9Z4 PAC:18131294 Citrus sinensis 372  
orange1.1g023218m A0A067EIG3 PAC:18131295 Citrus sinensis 285  
AT4G35650.1 O81796 PAC:19648743 Arabidopsis thaliana 368  
AT4G35260.1 Q8LFC0 PAC:19648968 Arabidopsis thaliana 367  
AT5G03290.1 Q945K7 PAC:19669239 Arabidopsis thaliana 374  
AT5G14200.3 B9DHH9 PAC:19672907 Arabidopsis thaliana 388  
AT5G14200.2 F4K5H6 PAC:19672908 Arabidopsis thaliana 300  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8053675
            1939242
            1748999
            2682654
            7773180