3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003871 | IPR002629 |
| GO:0008270 | IPR002629 |
| GO:0009086 | IPR002629 |
| Type: | Domain | Name: | Cobalamin-independent methionine synthase MetE, C-terminal/archaeal |
| Description: | Methionine synthases catalyse the the final step of methionine biosynthesis. Two apparently unrelated families of proteins catalyse this step: cobalamin-dependent methionine synthase, which catalyses the transfer of a methyl group from N5-methyltetrahydrofolate to L-homocysteine and requires cobalamin as a cofactor (MetH; 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase; ) and cobalamin-independent methionine synthase, which catalyses the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine without using an intermediate methyl carrier (MetE; 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase; ). These enzymes display no detectable sequence homology between them, but both require zinc for activation and binding to L-homocysteine. Organisms that cannot obtain cobalamin (vitamin B12) encode only the cobalamin-independent enzyme. Escherichia coli and many other bacteria express both enzymes []. Mammals utilise only cobalamin-dependent methionine synthase, while plants and yeasts utilise only the cobalamin-independent enzyme.The N-terminal half and C-terminal half of MetE in E. coli show some sequence similarity, indicating that the metE gene has evolved from an ancestral metE gene by duplication []. This entry represents a the C-terminal domain of cobalamin-independent methionine synthase (MetE) from bacteria and plants. It also includes archaeal proteins where this domain corresponds to the entire length of the protein []. | Short Name: | Met_Synth_C/arc |
| GO Term | Gene Name |
|---|---|
| GO:0003871 | IPR002629 |
| GO:0008270 | IPR002629 |
| GO:0009086 | IPR002629 |
