Protein Domain : IPR021190

Type:  Family Name:  Peptidase M10A
Description:  The MEROPS peptidase family M10, subfamily M10A, consists of extracellular metalloproteases, such as collagenase and stromelysin, that degrade the extracellular matrix and are known as matrixins or matrix metalloproteinases (MMPs). They are zinc-dependent, calcium-activated proteases synthesised as inactive precursors(zymogens), which are proteolytically cleaved to yield the active enzyme [, ].All matrixins and related proteins possess two domains: an N-terminal domain, and a zinc-binding active site domain. The N-terminal domainpeptide, cleaved during the activation step, includes a conserved PRCGVPDV octapeptide, known as the cysteine switch, whose Cys residue chelates theactive site zinc atom, rendering the enzyme inactive [, ]. The active enzyme degrades components of the extracellular matrix, playing a role in the initial steps of tissue remodelling during morphogenesis, wound healing, angiogenesis and tumour invasion [, ]. Although it was initially thought that the primary function of these enzymes is to degrade proteins of the extracellular matrix, MMPs have a much broader spectrum of activity that includes the proteolytic processing of cytokines, growth factors, growth factor receptors, and cell adhesion molecules [, ]. Short Name:  Pept_M10A
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6 Child Features

DB identifier Type Name
IPR016293 Family Peptidase M10A, stromelysin-type
IPR028736 Family Matrix metalloproteinase-26
IPR028708 Family 72kDa type IV collagenase
IPR028707 Family Matrilysin
IPR028687 Family Matrix metalloproteinase-23
IPR028688 Family Matrix metalloproteinase-9

8 Contains

DB identifier Type Name
IPR002477 Domain Peptidoglycan binding-like
IPR006026 Domain Peptidase, metallopeptidase
IPR001818 Domain Peptidase M10, metallopeptidase
IPR000585 Domain Hemopexin-like domain
IPR018487 Repeat Hemopexin-like repeats
IPR021805 Domain Peptidase M10A, matrix metallopeptidase, C-terminal
IPR018486 Conserved_site Hemopexin, conserved site
IPR021158 Binding_site Peptidase M10A, cysteine switch, zinc binding site

1 Cross References

Identifier
PR00138

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004222 IPR021190
GO:0008270 IPR021190
GO:0006508 IPR021190
GO:0031012 IPR021190

4 Ontology Annotations

GO Term Gene Name
GO:0004222 IPR021190
GO:0008270 IPR021190
GO:0006508 IPR021190
GO:0031012 IPR021190

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
13930 D8RFP7 PAC:15412210 Selaginella moellendorffii 301  
110370 D8S744 PAC:15406730 Selaginella moellendorffii 361  
evm.model.supercontig_29.169 PAC:16416198 Carica papaya 368  
evm.model.supercontig_5.334 PAC:16421456 Carica papaya 357  
29736.m002110 B9S2J2 PAC:16807215 Ricinus communis 364  
29822.m003413 B9RUG6 PAC:16809783 Ricinus communis 311  
29822.m003414 B9RUG7 PAC:16809784 Ricinus communis 321  
30174.m008806 B9RD50 PAC:16822451 Ricinus communis 363  
27428.m000110 B9T6S0 PAC:16798283 Ricinus communis 226  
28619.m000044 B9T8P6 PAC:16801278 Ricinus communis 325  
Cucsa.330820.1 PAC:16978216 Cucumis sativus 292  
Cucsa.011110.1 PAC:16951372 Cucumis sativus 295  
Cucsa.158720.1 PAC:16965165 Cucumis sativus 295  
Cucsa.158820.1 PAC:16965175 Cucumis sativus 295  
Cucsa.158710.1 A0A0A0KS47 PAC:16965164 Cucumis sativus 313  
Cucsa.158730.1 PAC:16965166 Cucumis sativus 293  
Cucsa.158740.1 A0A0A0KU08 PAC:16965167 Cucumis sativus 316  
Cucsa.158750.1 A0A0A0KS39 PAC:16965168 Cucumis sativus 319  
Cucsa.158760.1 PAC:16965169 Cucumis sativus 291  
Cucsa.158770.1 PAC:16965170 Cucumis sativus 267  
Cucsa.158780.1 PAC:16965171 Cucumis sativus 292  
Cucsa.158790.1 PAC:16965172 Cucumis sativus 255  
Cucsa.158800.1 PAC:16965173 Cucumis sativus 264  
Cucsa.158810.1 A0A0A0KVC8 PAC:16965174 Cucumis sativus 303  
Cucsa.356580.1 PAC:16980318 Cucumis sativus 291  
Cucsa.356590.1 PAC:16980319 Cucumis sativus 185  
Cucsa.259810.1 PAC:16973078 Cucumis sativus 252  
Cucsa.275230.1 A0A0A0KRY9 PAC:16973958 Cucumis sativus 366  
Cucsa.301780.1 A0A0A0KRA5 PAC:16975655 Cucumis sativus 370  
orange1.1g035681m A0A067DG72 PAC:18130319 Citrus sinensis 320  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2167841
            2841336
            2551898
            1988438
            11544020
            19800373