Protein Domain : IPR002182

Type:  Domain Name:  NB-ARC
Description:  This is the NB-ARC domain, a novel signalling motif found in bacteria and eukaryotes, shared by plant resistance gene products and regulators of cell death in animals []. This domain has been structurally characterised in the human protein apoptotic protease-activating factor 1 (Apaf-1) []. It contains the three-layered alpha-beta fold and subsequent short alpha-helical region characteristic of the AAA+ ATPase domain superfamily. While this domain is thought to bind and hyrolyse ATP, only ADP binding has been experimentally verified. It is proposed that binding and hydrolysis of ATP by this domain induces conformational changes the the overall protein, leading to formation of the apoptosome. Short Name:  NB-ARC
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0 Child Features

0 Contains

1 Cross References

Identifier
PF00931

2 Found Ins

DB identifier Type Name
IPR016854 Family Apoptosis regulator, Ced-4
IPR017251 Family Apoptotic protease-activating factor 1

1 GO Annotation

GO Term Gene Name
GO:0043531 IPR002182

1 Ontology Annotations

GO Term Gene Name
GO:0043531 IPR002182

0 Parent Features

104773 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
411495 D8RI45 PAC:15408674 Selaginella moellendorffii 273  
415649 D8RWT3 PAC:15421740 Selaginella moellendorffii 1383  
105865 D8S0D0 PAC:15418013 Selaginella moellendorffii 195  
37836 D8S4H8 PAC:15415267 Selaginella moellendorffii 171  
110698 D8S7F2 PAC:15409118 Selaginella moellendorffii 266  
110652 D8S7E6 PAC:15408993 Selaginella moellendorffii 188  
110560 D8S7Q2 PAC:15408205 Selaginella moellendorffii 1103  
110609 D8S7E3 PAC:15408882 Selaginella moellendorffii 206  
110600 D8S7E8 PAC:15408879 Selaginella moellendorffii 266  
418928 D8S792 PAC:15410584 Selaginella moellendorffii 616  
419040 D8S7M5 PAC:15406550 Selaginella moellendorffii 658  
111732 D8S9M7 PAC:15412702 Selaginella moellendorffii 198  
444345 D8S968 PAC:15415932 Selaginella moellendorffii 734  
429055 D8T4X2 PAC:15413962 Selaginella moellendorffii 936  
26669 D8SZ68 PAC:15403514 Selaginella moellendorffii 195  
427019 D8SY91 PAC:15407801 Selaginella moellendorffii 1346  
90705 D8RCG2 PAC:15414849 Selaginella moellendorffii 158  
evm.TU.contig_28428.2 PAC:16429591 Carica papaya 676  
evm.TU.contig_32363.1 PAC:16430099 Carica papaya 1656  
evm.model.supercontig_10.207 PAC:16404568 Carica papaya 1128  
evm.model.supercontig_10.213 PAC:16404575 Carica papaya 1083  
evm.model.supercontig_10.211 PAC:16404573 Carica papaya 309  
evm.model.supercontig_10.212 PAC:16404574 Carica papaya 964  
evm.model.supercontig_10.227 PAC:16404590 Carica papaya 1046  
evm.model.supercontig_125.42 PAC:16407273 Carica papaya 903  
evm.model.supercontig_16.142 PAC:16409988 Carica papaya 391  
evm.model.supercontig_16.140 PAC:16409986 Carica papaya 269  
evm.model.supercontig_16.141 PAC:16409987 Carica papaya 910  
evm.model.supercontig_16.145 PAC:16409991 Carica papaya 228  
evm.model.supercontig_16.137 PAC:16409982 Carica papaya 1437  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9545207
            16208361