| Type: | Domain | Name: | Chitinase insertion domain |
| Description: | This entry represents the chitinase insertion domain (CID) that is found in chitinases or chitinase-like proteins. It is composed of five or six anti-parallel beta-strands and one alpha-helix and it inserts between the seventh alpha-helix and seventh beta-strand of the TIM barrel []. The CID domain forms a wall alongside the TIM barrel substrate-binding cleft of chitinase which increases the depth of the cleft. Family 18 chitinases (also known as glycosyl hydrolase 18 family) can be classified into three subfamilies: A, B, and C. The CID domain can be found in the subfamily A, but is absent in the subfamily B []. Some mammalian glycoproteins with various functions also consist of a TIM domain and a CID domain, such as human cartilage glycoprotein-39 (HCgp-39), also known as chitinase-3-like protein 1 []. | Short Name: | Chitinase_insertion |
