| Type: | Family | Name: | Serine-tRNA ligase, type1 |
| Description: | Serine-tRNA ligase () exists as monomer and belongs to the aminoacyl-tRNA synthetase class IIa []. It catalyses the attachment of serine to tRNA (Ser). It is also able to aminoacylate tRNA (Sec) with serine, to form the misacylated tRNA L-seryl-tRNA (Sec), which will be further converted into selenocysteinyl-tRNA (Sec). The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. | Short Name: | Ser-tRNA-ligase_type_1 |
| GO Term | Gene Name |
|---|---|
| GO:0000166 | IPR002317 |
| GO:0004828 | IPR002317 |
| GO:0005524 | IPR002317 |
| GO:0006434 | IPR002317 |
| GO:0005737 | IPR002317 |
| GO Term | Gene Name |
|---|---|
| GO:0000166 | IPR002317 |
| GO:0004828 | IPR002317 |
| GO:0005524 | IPR002317 |
| GO:0006434 | IPR002317 |
| GO:0005737 | IPR002317 |
