Protein Domain : IPR022953

Type:  Family Name:  ATP-dependent 6-phosphofructokinase
Description:  The enzyme-catalysed transfer of a phosphoryl group from ATP is an important reaction in a wide variety of biological processes []. Oneenzyme that utilises this reaction is phosphofructokinase (PFK), which catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate, a key regulatory step in the glycolytic pathway [, ]. PFK exists as a homotetramer in bacteria and mammals (where each monomer possesses 2 similar domains), and as an octomer in yeast (where there are4 alpha- (PFK1) and 4 beta-chains (PFK2), the latter, like the mammalian monomers, possessing 2 similar domains []). PFK is ~300 amino acids in length, and structural studies of the bacterial enzyme have shown it comprises two similar (alpha/beta) lobes: one involved inATP binding and the other housing both the substrate-binding site and the allosteric site (a regulatory binding site distinct from the active site, but that affects enzyme activity). The identical tetramer subunits adopt 2 different conformations: in a 'closed' state, the bound magnesium ion bridges the phosphoryl groups of the enzyme products (ADP and fructose-1,6-bisphosphate); and in an 'open' state, the magnesium ion binds only the ADP [], as the 2 products are now further apart. These conformations arethought to be successive stages of a reaction pathway that requires subunit closure to bring the 2 molecules sufficiently close to react [].Deficiency in PFK leads to glycogenosis type VII (Tauri's disease), an autosomal recessive disorder characterised by severe nausea, vomiting,muscle cramps and myoglobinuria in response to bursts of intense or vigorous exercise []. Sufferers are usually able to lead a reasonablyordinary life by learning to adjust activity levels []. Short Name:  ATP_PFK
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7 Child Features

DB identifier Type Name
IPR012004 Family Pyrophosphate-dependent phosphofructokinase TP0108-type
IPR011183 Family Pyrophosphate-dependent phosphofructokinase PfpB
IPR012003 Family ATP-dependent 6-phosphofructokinase, prokaryotic-type
IPR009161 Family ATP-dependent 6-phosphofructokinase, eukaryotic-type
IPR011403 Family Pyrophosphate-dependent phosphofructokinase TM0289 type
IPR011404 Family Pyrophosphate--fructose 6-phosphate 1-phosphotransferase, XF0274
IPR011405 Family Pyrophosphate-dependent phosphofructokinase SMc01852 type

0 Contains

1 Cross References

Identifier
PR00476

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003872 IPR022953
GO:0006002 IPR022953
GO:0006096 IPR022953

3 Ontology Annotations

GO Term Gene Name
GO:0003872 IPR022953
GO:0006002 IPR022953
GO:0006096 IPR022953

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171380 D8RGP9 PAC:15408178 Selaginella moellendorffii 616  
187341 D8TCD9 PAC:15410645 Selaginella moellendorffii 441  
438337 D8QW81 PAC:15420368 Selaginella moellendorffii 472  
150344 D8RVK8 PAC:15413250 Selaginella moellendorffii 511  
234662 D8SNS2 PAC:15404668 Selaginella moellendorffii 560  
146031 D8RCZ6 PAC:15421131 Selaginella moellendorffii 404  
evm.model.supercontig_1180.1 PAC:16406512 Carica papaya 567  
evm.model.supercontig_13.254 PAC:16407774 Carica papaya 211  
evm.model.supercontig_27.198 PAC:16415576 Carica papaya 467  
evm.model.supercontig_55.34 PAC:16422599 Carica papaya 533  
evm.model.supercontig_7.225 PAC:16425137 Carica papaya 317  
evm.model.supercontig_78.43 PAC:16426220 Carica papaya 544  
29836.m000568 B9SGA6 PAC:16810281 Ricinus communis 561  
29842.m003527 B9RXE7 PAC:16810660 Ricinus communis 552  
29912.m005351 B9RKE5 PAC:16813228 Ricinus communis 632  
30146.m003489 B9RQC7 PAC:16819611 Ricinus communis 543  
30147.m014328 B9R9Y5 PAC:16820339 Ricinus communis 522  
27749.m000346 B9SXI3 PAC:16799091 Ricinus communis 431  
Cucsa.397620.1 PAC:16983525 Cucumis sativus 400  
Cucsa.397620.2 PAC:16983526 Cucumis sativus 394  
Cucsa.044920.1 A0A0A0KH95 PAC:16953274 Cucumis sativus 567  
Cucsa.044440.1 A0A0A0KL11 PAC:16953207 Cucumis sativus 454  
Cucsa.094110.1 PAC:16957697 Cucumis sativus 529  
Cucsa.272460.2 PAC:16973725 Cucumis sativus 543  
Cucsa.288660.2 PAC:16975109 Cucumis sativus 433  
orange1.1g015095m PAC:18133804 Citrus sinensis 413  
orange1.1g016855m PAC:18133805 Citrus sinensis 381  
orange1.1g019697m A0A067DAH6 PAC:18133806 Citrus sinensis 337  
orange1.1g009444m PAC:18133802 Citrus sinensis 534  
orange1.1g011540m PAC:18133803 Citrus sinensis 483  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7825568
            2975709
            2953977
            12023862