Type: | Family | Name: | OTU domain-containing protein 5/Otubain-like deubiquitinase 1 |
Description: | Proteins in this entry are deubiquitinases, including OTUD5 (OTU domain-containing protein 5) from animals and otubain-like deubiquitinase 1 (OTLD1, AT2G27350, ) from Arabidopsis. Human OTUD5, also known as DUBA, functions as negative regulator of the innate immune system [, ] and is a post-translational suppressor of IL-17 production in T cells []. Arabidopsis OTLD1 is involved in transcriptional gene repression via histone deubiquitination and demethylation []. | Short Name: | OTU5/OTLD1 |